guangnanmycin

naturalproductmech:mibig-4d218fcef2 MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	AFUMTTRIOUSWKA-QCXAANFUSA-N
SMILES	CC(/C=C/C(C/C=C(C)/CC[C@](CC(O)=O)(SSC)CC1=O)=C)=C/C2=CSC(C3(CC3)N1)=N2
Stereochemistry	fully defined
Cross-references	npatlas:NPA028328

Filing pathway

Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptomyces sp. CB01883 NCBITaxon:1703943	SOURCE_ASSERTION	mibig:BGC0001611	DOI:10.1073/pnas.1716245115

Occurrences 0

None cited.

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0001611	Streptomyces sp. CB01883 NCBITaxon:1703943	CLUSTER_UNSTATED	genbank:MF925481.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Causal graph — biosynthesis 4 nodes, 3 edges

MITE-asserted GnmP persulfide methylation yielding the exact guangnanmycin structure. The native CB01883 reference is grounded in NCBIProtein because the source's former UniProtKB accession is inactive and its replacement identifier is UniParc, not UniProtKB. Primary experiments were not inspected. Producer/BGC grades and all source fields are unchanged; not full-record sign-off.

Subject	Predicate	Object	Notes	Evidence
GnmP native reference from Streptomyces sp. CB01883	is_database_reported_catalyst_of	MITE-reported persulfide methylation	MITE supplies functional attribution; GenPept/genomic/UniParc records establish identity only. No current UniProtKB example was selected: the exact organism/gene query was empty and the archive's UniProt cross-reference is inactive. This is a bounded search, not proof that no future or differently annotated entry can exist. No domain-site, rate, knockout phenotype, methyl-donor identity or physical-complex claim is adopted.	https://github.com/mite-standard/mite_data/blob/6eacd913b2036376031072f69cbb33908f132998/mite_data/data/MITE0000105.json https://www.ncbi.nlm.nih.gov/protein/ATY69565.1 https://www.ncbi.nlm.nih.gov/nuccore/MF925481.1 https://www.uniprot.org/uniparc/UPI000938C7BA reference https://github.com/mite-standard/mite_data/blob/6eacd913b2036376031072f69cbb33908f132998/mite_data/data/MITE0000105.json evidence type DATABASE_ASSERTION retrieved on 2026-10-07 notes MITE0000105 version 2, active, at the pinned commit. Its GnmP enzyme description, methylation classification and reaction example support the depicted persulfide methylation. Its in-vitro and knockout evidence codes are not independently inspected experiments; the cited primary paper was inaccessible. snippet Persulfide methyltransferase reference https://www.ncbi.nlm.nih.gov/protein/ATY69565.1 evidence type DATABASE_ASSERTION retrieved on 2026-10-07 notes Complete author-supplied conceptual translation and independent coded_by inspected: gnmP, Streptomyces sp. CB01883/taxon 1703943, 248 residues. Generic methyltransferase and domain annotations are not compound-specific assay proof. reference https://www.ncbi.nlm.nih.gov/nuccore/MF925481.1 evidence type CURATOR_INFERENCE retrieved on 2026-10-07 notes Complete 747-nt negative-strand CDS at 31255..32001, table 11, codon_start 1. Full translation equals the CDS annotation, independent ATY69565.1 and UniParc248aa; independent coded_by DNA/coordinates match. This proves the genomic reference, not a historical expression construct or assay-stock sequence. reference https://www.uniprot.org/uniparc/UPI000938C7BA evidence type DATABASE_ASSERTION retrieved on 2026-10-07 notes Sequence archive matches all 248 residues and links active ATY69565 version 1 for CB01883. Its UniProtKB cross-reference A0A2H4T153 is inactive. UniParc is not an organism-specific UniProtKB accession, and the record's other organism/RefSeq links are not selected as replacements for the native producer reference.
MITE-encoded persulfide precursor	is_database_reported_substrate_of	MITE-reported persulfide methylation	The node denotes the substrate encoded in the pinned MITE example. No external chemical identifier, additional precursor generation step or independently inspected assay is asserted.	https://github.com/mite-standard/mite_data/blob/6eacd913b2036376031072f69cbb33908f132998/mite_data/data/MITE0000105.json reference https://github.com/mite-standard/mite_data/blob/6eacd913b2036376031072f69cbb33908f132998/mite_data/data/MITE0000105.json evidence type DATABASE_ASSERTION retrieved on 2026-10-07 notes MITE0000105 version 2, active, at the pinned commit. Its GnmP enzyme description, methylation classification and reaction example support the depicted persulfide methylation. Its in-vitro and knockout evidence codes are not independently inspected experiments; the cited primary paper was inaccessible.
MITE-reported persulfide methylation	has_database_reported_product	Guangnanmycin, exact owner structure	The pinned MITE product matches the full owner InChIKey AFUMTTRIOUSWKA-QCXAANFUSA-N and defined stereochemistry using the repository structure helper and RDKit 2026.03.5. The example's intermediate flag is not independent proof of pathway finality. Source correspondence to BGC0001611 and MF925481.1 does not upgrade the owner's SOURCE_ASSERTION producer or CLUSTER_UNSTATED BGC grade.	https://github.com/mite-standard/mite_data/blob/6eacd913b2036376031072f69cbb33908f132998/mite_data/data/MITE0000105.json reference https://github.com/mite-standard/mite_data/blob/6eacd913b2036376031072f69cbb33908f132998/mite_data/data/MITE0000105.json evidence type DATABASE_ASSERTION retrieved on 2026-10-07 notes MITE0000105 version 2, active, at the pinned commit. Its GnmP enzyme description, methylation classification and reaction example support the depicted persulfide methylation. Its in-vitro and knockout evidence codes are not independently inspected experiments; the cited primary paper was inaccessible.

Every edge carries its own citation; an uncited edge is refused by the corpus tests.

Explore across X-Mech

AntibioticMech (guangnanmycin) ↗ MediaIngredientMech (naturalproductmech:mibig-4d218fcef2) ↗ TaxonMech: Streptomyces sp. CB01883 (NCBITaxon:1703943) ↗ PathwayMech (mibig:BGC0001611) ↗

Provenance

Source concept	Source	Version
BGC0001611	MIBIG	4

This page is generated from data/natural_products/amino_acids_and_peptides/guangnanmycin.yaml, which is generated from the committed inventories. Neither is edited by hand.