HC toxin
CHEBI:48028 EXACT SEEDED
A homodetic cyclic tetrapeptide made up from L-alanyl, D-alanyl, L-prolyl and 2-amino-8-oxo-9,10-epoxydecanoyl residues.
Structure
| Standard InChIKey | GNYCTMYOHGBSBI-KVUCBBCISA-N |
|---|---|
| SMILES | C[C@@H]1C(=O)N[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@H](C(=O)N1)C)CCCCCC(=O)C3CO3 |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | pubchem:107864 |
Filing pathway
Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Alternaria jesenskae NCBITaxon:378183 |
SOURCE_ASSERTION | mibig:BGC0001166 | PMID:23865912 |
Occurrences 1
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Alternaria jesenskae NCBITaxon:378183 |
LOTUS | DOI:10.1186/1471-2180-13-165 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001166 | Alternaria jesenskae NCBITaxon:378183 |
CLUSTER_UNSTATED | genbank:KC862269.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Open questions 1
name-disagreement — ChEBI calls this structure 'HC toxin' and MIBiG calls it 'HC-toxin'. They share a Standard InChIKey, so if the names denote different compounds then one upstream record has the wrong structure. Check which.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001166 | MIBIG | 5 |
| CHEBI:48028 | CHEBI | 3-star |
This page is generated from data/natural_products/amino_acids_and_peptides/hc-toxin.yaml, which is generated from the committed inventories. Neither is edited by hand.