himastatin
CHEBI:190009 EXACT SEEDED antibacterial
A dimeric cyclohexadepsipeptide with formula C72H104N14O20. It is an antibiotic isolated from Streptomyces hygroscopicus and exhibits antitumor and antibacterial activity.
Structure
| Standard InChIKey | OZPNLJQULOIOGU-UPABGHPRSA-N |
|---|---|
| SMILES | [H][C@@]12NC3=CC=C(C=C3[C@]1(O)C[C@@H]1N2C(=O)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]2C[C@@H](O)CNN2C(=O)[C@@H](OC(=O)[C@H](NC1=O)C(C)C)C(C)C)[C@H](C)O)C1=CC=C2N[C@@]3([H])N4[C@@H](C[C@@]3(O)C2=C1)C(=O)N[C@H](C(C)C)C(=O)O[C@@H](C(C)C)C(=O)N1NC[C@H](O)C[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]([C@H](C)O)C4=O |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA016115 |
Filing pathway
Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces himastatinicus ATCC 53653 NCBITaxon:457427 |
SOURCE_ASSERTION | mibig:BGC0001117 | PMID:21726028 |
Occurrences 4
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces hygroscopicus NCBITaxon:1912 |
LOTUS | DOI:10.7164/ANTIBIOTICS.43.956 |
| Streptomyces hygroscopicus NCBITaxon:1912 |
LOTUS | DOI:10.7164/ANTIBIOTICS.43.961 |
| Streptomyces hygroscopicus NCBITaxon:1912 |
LOTUS | DOI:10.7164/ANTIBIOTICS.49.299 |
| Streptomyces himastatinicus ATCC 53653 NCBITaxon:457427 |
CHEBI | PMID:2211363 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001117 | Streptomyces himastatinicus ATCC 53653 NCBITaxon:457427 |
CLUSTER_UNSTATED | genbank:FR823394.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Elsewhere in the fleet
- AntibioticMech — CHEBI:190009 (same structure, same inchikey)
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001117 | MIBIG | 5 |
| CHEBI:190009 | CHEBI | 3-star |
This page is generated from data/natural_products/amino_acids_and_peptides/himastatin.yaml, which is generated from the committed inventories. Neither is edited by hand.