isocomplestatin
naturalproductmech:mibig-08763e9bdc REVIEW_NEEDED SEEDED antiviral
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
Structure
| Standard InChIKey | JJGZGELTZPACID-OTLJHNKQSA-N |
|---|---|
| SMILES | CN1[C@@H](CC2=CC=C(OC3=CC4=CC(=C3O)C3=CC5=C(C=C3)C(C[C@@H](NC(=O)C(=O)C3=CC(Cl)=C(O)C(Cl)=C3)C(=O)N[C@H](C3=CC(Cl)=C(O)C(Cl)=C3)C(=O)N[C@H]4C(=O)N[C@H](C3=CC(Cl)=C(O)C(Cl)=C3)C1=O)=CN5)C=C2)C(=O)N[C@@H](C(O)=O)C1=CC=C(O)C=C1 |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA0750 |
Filing pathway
Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces lavendulae NCBITaxon:1914 |
SOURCE_ASSERTION | mibig:BGC0000326 | PMID:11447274 |
Occurrences 11
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.1016/S0040-4039(98)01145-9 |
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.1021/NP000632Z |
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.7164/ANTIBIOTICS.50.58 |
| Streptomyces sp. NCBITaxon:1931 |
CHEBI | PMID:11473415 |
| Streptomyces sp. NCBITaxon:1931 |
CHEBI | PMID:9066767 |
| Streptomyces lavendulae NCBITaxon:1914 |
LOTUS | DOI:10.1002/CBIC.201600241 |
| Streptomyces lavendulae NCBITaxon:1914 |
LOTUS | DOI:10.1016/S0006-291X(03)01231-2 |
| Streptomyces lavendulae NCBITaxon:1914 |
LOTUS | DOI:10.1016/S0040-4039(01)80562-1 |
| Streptomyces lavendulae NCBITaxon:1914 |
LOTUS | DOI:10.7164/ANTIBIOTICS.42.236 |
| Streptomyces lavendulae NCBITaxon:1914 |
LOTUS | DOI:10.7164/ANTIBIOTICS.47.1173 |
| Streptomyces lavendulae NCBITaxon:1914 |
LOTUS | DOI:10.7164/ANTIBIOTICS.50.66 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000326 | Streptomyces lavendulae NCBITaxon:1914 |
CLUSTER_UNSTATED | genbank:AF386507.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
Elsewhere in the fleet
- AntibioticMech — CHEBI:65619 (same structure, same inchikey)
- AntibioticMech — CHEBI:66093 (same structure, same inchikey)
Explore across X-Mech
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000326 | MIBIG | 5 |
| CHEBI:65619 | CHEBI | 3-star |
| CHEBI:66093 | CHEBI | 3-star |
This page is generated from data/natural_products/amino_acids_and_peptides/isocomplestatin.yaml, which is generated from the committed inventories. Neither is edited by hand.