kistamicin A
naturalproductmech:mibig-213b96e278 MINTED SEEDED
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
Structure
| Standard InChIKey | UFHMIPMOTWJTKL-UHFFFAOYSA-N |
|---|---|
| SMILES | NC(CC1=CC=C(O)C=C1)C(=O)NC1CC2=CNC3=C2C=CC(=C3)C2=CC3=CC(OC4=CC=C(CC5NC(=O)C(NC(=O)C3NC(=O)C(NC1=O)C1=CC(O)=CC(O)=C1)C1=CC=C(OC3=C(O)C=CC(=C3)C(NC5=O)C(O)=O)C(Cl)=C1)C=C4)=C2O |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | npatlas:NPA017605 |
Filing pathway
Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Nonomuraea sp. ATCC 55076 NCBITaxon:1909395 |
SOURCE_ASSERTION | mibig:BGC0001635 | PMID:28626548 |
Occurrences 1
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Nonomuraea NCBITaxon:83681 |
LOTUS | DOI:10.1039/C6MD00637J |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001635 | Nonomuraea sp. ATCC 55076 NCBITaxon:1909395 |
CLUSTER_UNSTATED | genbank:CP017717.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
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Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001635 | MIBIG | 4 |
This page is generated from data/natural_products/amino_acids_and_peptides/kistamicin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.