NaturalProductMech

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leinamycin

naturalproductmech:mibig-706609b57e MINTED SEEDED cytotoxic

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.
What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKeyZHTRILQJTPJGNK-FYBAATNNSA-N
SMILESC[C@@H]1C2=NC(=CS2)/C=C\C=C\C(=O)[C@@H](/C=C(/CC[C@@]3(CC(=O)N1)[C@@](C(=O)SS3=O)(C)O)\C)O
Stereochemistry undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-referencespubchem:9849230

Filing pathway

Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

TaxonBasisClusterEvidence
Streptomyces atroolivaceus
NCBITaxon:66869		 BGC_CHARACTERIZED mibig:BGC0001101 PMID:12446651

Occurrences 5

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

TaxonSourceReference
Streptomyces atroolivaceus
NCBITaxon:66869		 LOTUS DOI:10.1007/S00253-016-7864-2
Streptomyces atroolivaceus
NCBITaxon:66869		 LOTUS DOI:10.1021/NP050467T
Streptomyces atroolivaceus
NCBITaxon:66869		 LOTUS DOI:10.1074/JBC.M702814200
Streptomyces atroolivaceus
NCBITaxon:66869		 LOTUS DOI:10.1128/JB.00173-06
Streptomyces atroolivaceus
NCBITaxon:66869		 LOTUS DOI:10.1128/JB.184.24.7013-7024.2002

Biosynthetic gene clusters 1

AccessionHostLocus evidenceGenome
mibig:BGC0001101 Streptomyces atroolivaceus
NCBITaxon:66869 		CLUSTER_DEMONSTRATED genbank:AF484556.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

PRODUCERS & OCCURRENCE 1 producer (1 causal) 5 cited occurrences BIOSYNTHETIC LOCUS 1 gene cluster 0 curated pathway steps NATURAL PRODUCT leinamycin naturalproductmech:mibig-706609b57e Amino acids and peptides TARGETS & BIOACTIVITY 0 molecular targets 25 bioactivities · 0 graphs

Bioactivities 25

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

AssayResultTarget enzymeSource detail
NCI Yeast Anticancer Drug Screen. Data for the bub3 strainACTIVENot recorded
pubchem.aid:167
assay
NCI Yeast Anticancer Drug Screen. Data for the bub3 strain
evidence
  • reference
    pubchem.aid:167
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 167, deposited by DTP/NCI; assay type Other.
call
ACTIVE
activity class
CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the cln2 rad14 strainACTIVENot recorded
pubchem.aid:165
assay
NCI Yeast Anticancer Drug Screen. Data for the cln2 rad14 strain
evidence
  • reference
    pubchem.aid:165
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 165, deposited by DTP/NCI; assay type Other.
call
ACTIVE
activity class
CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the mec2-1 strainACTIVENot recorded
pubchem.aid:157
assay
NCI Yeast Anticancer Drug Screen. Data for the mec2-1 strain
evidence
  • reference
    pubchem.aid:157
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 157, deposited by DTP/NCI; assay type Other.
call
ACTIVE
activity class
CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the mlh1 rad18 strainACTIVENot recorded
pubchem.aid:175
assay
NCI Yeast Anticancer Drug Screen. Data for the mlh1 rad18 strain
evidence
  • reference
    pubchem.aid:175
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 175, deposited by DTP/NCI; assay type Other.
call
ACTIVE
activity class
CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the rad50 strainACTIVENot recorded
pubchem.aid:155
assay
NCI Yeast Anticancer Drug Screen. Data for the rad50 strain
evidence
  • reference
    pubchem.aid:155
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 155, deposited by DTP/NCI; assay type Other.
call
ACTIVE
activity class
CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the sgs1 mgt1 strainACTIVENot recorded
pubchem.aid:161
assay
NCI Yeast Anticancer Drug Screen. Data for the sgs1 mgt1 strain
evidence
  • reference
    pubchem.aid:161
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 161, deposited by DTP/NCI; assay type Other.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the 786-0 Renal cell lineACTIVENot recorded
pubchem.aid:137
assay
NCI human tumor cell line growth inhibition assay. Data for the 786-0 Renal cell line
evidence
  • reference
    pubchem.aid:137
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 137, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the A498 Renal cell lineACTIVENot recorded
pubchem.aid:129
assay
NCI human tumor cell line growth inhibition assay. Data for the A498 Renal cell line
evidence
  • reference
    pubchem.aid:129
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 129, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell lineACTIVENot recorded
pubchem.aid:19
assay
NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line
evidence
  • reference
    pubchem.aid:19
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 19, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell lineACTIVENot recorded
pubchem.aid:139
assay
NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line
evidence
  • reference
    pubchem.aid:139
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 139, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the BT-549 Breast cell lineACTIVENot recorded
pubchem.aid:89
assay
NCI human tumor cell line growth inhibition assay. Data for the BT-549 Breast cell line
evidence
  • reference
    pubchem.aid:89
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 89, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Renal cell lineACTIVENot recorded
pubchem.aid:131
assay
NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Renal cell line
evidence
  • reference
    pubchem.aid:131
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 131, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Leukemia cell lineACTIVENot recorded
pubchem.aid:119
assay
NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Leukemia cell line
evidence
  • reference
    pubchem.aid:119
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 119, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the COLO 205 Colon cell lineACTIVENot recorded
pubchem.aid:67
assay
NCI human tumor cell line growth inhibition assay. Data for the COLO 205 Colon cell line
evidence
  • reference
    pubchem.aid:67
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 67, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the DLD-1 Colon cell lineACTIVENot recorded
pubchem.aid:69
assay
NCI human tumor cell line growth inhibition assay. Data for the DLD-1 Colon cell line
evidence
  • reference
    pubchem.aid:69
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 69, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the DMS 114 Small Cell Lung cell lineACTIVENot recorded
pubchem.aid:63
assay
NCI human tumor cell line growth inhibition assay. Data for the DMS 114 Small Cell Lung cell line
evidence
  • reference
    pubchem.aid:63
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 63, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the DMS 273 Small Cell Lung cell lineACTIVENot recorded
pubchem.aid:61
assay
NCI human tumor cell line growth inhibition assay. Data for the DMS 273 Small Cell Lung cell line
evidence
  • reference
    pubchem.aid:61
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 61, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell lineACTIVENot recorded
pubchem.aid:43
assay
NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line
evidence
  • reference
    pubchem.aid:43
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 43, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the EKVX Non-Small Cell Lung cell lineACTIVENot recorded
pubchem.aid:21
assay
NCI human tumor cell line growth inhibition assay. Data for the EKVX Non-Small Cell Lung cell line
evidence
  • reference
    pubchem.aid:21
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 21, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HCC-2998 Colon cell lineACTIVENot recorded
pubchem.aid:77
assay
NCI human tumor cell line growth inhibition assay. Data for the HCC-2998 Colon cell line
evidence
  • reference
    pubchem.aid:77
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 77, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HCT-116 Colon cell lineACTIVENot recorded
pubchem.aid:79
assay
NCI human tumor cell line growth inhibition assay. Data for the HCT-116 Colon cell line
evidence
  • reference
    pubchem.aid:79
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 79, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HCT-15 Colon cell lineACTIVENot recorded
pubchem.aid:71
assay
NCI human tumor cell line growth inhibition assay. Data for the HCT-15 Colon cell line
evidence
  • reference
    pubchem.aid:71
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 71, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell lineACTIVENot recorded
pubchem.aid:125
assay
NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line
evidence
  • reference
    pubchem.aid:125
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 125, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HOP-18 Non-Small Cell Lung cell lineACTIVENot recorded
pubchem.aid:11
assay
NCI human tumor cell line growth inhibition assay. Data for the HOP-18 Non-Small Cell Lung cell line
evidence
  • reference
    pubchem.aid:11
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 11, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HOP-62 Non-Small Cell Lung cell lineACTIVENot recorded
pubchem.aid:9
assay
NCI human tumor cell line growth inhibition assay. Data for the HOP-62 Non-Small Cell Lung cell line
evidence
  • reference
    pubchem.aid:9
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 9, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
notes
50 further PubChem assay results are in data/raw/pubchem_bioassay.tsv but not written here.

Explore across X-Mech

AntibioticMech (leinamycin) ↗ MediaIngredientMech (naturalproductmech:mibig-706609b57e) ↗ TaxonMech: Streptomyces atroolivaceus (NCBITaxon:66869) ↗ PathwayMech (mibig:BGC0001101) ↗

Provenance

Source conceptSourceVersion
BGC0001101MIBIG5

This page is generated from data/natural_products/amino_acids_and_peptides/leinamycin.yaml, which is generated from the committed inventories. Neither is edited by hand.