leinamycin
naturalproductmech:mibig-706609b57e MINTED SEEDED cytotoxic
Structure
| Standard InChIKey | ZHTRILQJTPJGNK-FYBAATNNSA-N |
|---|---|
| SMILES | C[C@@H]1C2=NC(=CS2)/C=C\C=C\C(=O)[C@@H](/C=C(/CC[C@@]3(CC(=O)N1)[C@@](C(=O)SS3=O)(C)O)\C)O |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | pubchem:9849230 |
Filing pathway
Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces atroolivaceus NCBITaxon:66869 |
BGC_CHARACTERIZED | mibig:BGC0001101 | PMID:12446651 |
Occurrences 5
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces atroolivaceus NCBITaxon:66869 |
LOTUS | DOI:10.1007/S00253-016-7864-2 |
| Streptomyces atroolivaceus NCBITaxon:66869 |
LOTUS | DOI:10.1021/NP050467T |
| Streptomyces atroolivaceus NCBITaxon:66869 |
LOTUS | DOI:10.1074/JBC.M702814200 |
| Streptomyces atroolivaceus NCBITaxon:66869 |
LOTUS | DOI:10.1128/JB.00173-06 |
| Streptomyces atroolivaceus NCBITaxon:66869 |
LOTUS | DOI:10.1128/JB.184.24.7013-7024.2002 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001101 | Streptomyces atroolivaceus NCBITaxon:66869 |
CLUSTER_DEMONSTRATED | genbank:AF484556.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 25
| Assay | Result | Reference |
|---|---|---|
| NCI Yeast Anticancer Drug Screen. Data for the bub3 strain | ACTIVE | pubchem.aid:167 |
| NCI Yeast Anticancer Drug Screen. Data for the cln2 rad14 strain | ACTIVE | pubchem.aid:165 |
| NCI Yeast Anticancer Drug Screen. Data for the mec2-1 strain | ACTIVE | pubchem.aid:157 |
| NCI Yeast Anticancer Drug Screen. Data for the mlh1 rad18 strain | ACTIVE | pubchem.aid:175 |
| NCI Yeast Anticancer Drug Screen. Data for the rad50 strain | ACTIVE | pubchem.aid:155 |
| NCI Yeast Anticancer Drug Screen. Data for the sgs1 mgt1 strain | ACTIVE | pubchem.aid:161 |
| NCI human tumor cell line growth inhibition assay. Data for the 786-0 Renal cell line | ACTIVE | pubchem.aid:137 |
| NCI human tumor cell line growth inhibition assay. Data for the A498 Renal cell line | ACTIVE | pubchem.aid:129 |
| NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line | ACTIVE | pubchem.aid:19 |
| NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line | ACTIVE | pubchem.aid:139 |
| NCI human tumor cell line growth inhibition assay. Data for the BT-549 Breast cell line | ACTIVE | pubchem.aid:89 |
| NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Renal cell line | ACTIVE | pubchem.aid:131 |
| NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Leukemia cell line | ACTIVE | pubchem.aid:119 |
| NCI human tumor cell line growth inhibition assay. Data for the COLO 205 Colon cell line | ACTIVE | pubchem.aid:67 |
| NCI human tumor cell line growth inhibition assay. Data for the DLD-1 Colon cell line | ACTIVE | pubchem.aid:69 |
| NCI human tumor cell line growth inhibition assay. Data for the DMS 114 Small Cell Lung cell line | ACTIVE | pubchem.aid:63 |
| NCI human tumor cell line growth inhibition assay. Data for the DMS 273 Small Cell Lung cell line | ACTIVE | pubchem.aid:61 |
| NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line | ACTIVE | pubchem.aid:43 |
| NCI human tumor cell line growth inhibition assay. Data for the EKVX Non-Small Cell Lung cell line | ACTIVE | pubchem.aid:21 |
| NCI human tumor cell line growth inhibition assay. Data for the HCC-2998 Colon cell line | ACTIVE | pubchem.aid:77 |
| NCI human tumor cell line growth inhibition assay. Data for the HCT-116 Colon cell line | ACTIVE | pubchem.aid:79 |
| NCI human tumor cell line growth inhibition assay. Data for the HCT-15 Colon cell line | ACTIVE | pubchem.aid:71 |
| NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line | ACTIVE | pubchem.aid:125 |
| NCI human tumor cell line growth inhibition assay. Data for the HOP-18 Non-Small Cell Lung cell line | ACTIVE | pubchem.aid:11 |
| NCI human tumor cell line growth inhibition assay. Data for the HOP-62 Non-Small Cell Lung cell line | ACTIVE | pubchem.aid:9 |
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001101 | MIBIG | 5 |
This page is generated from data/natural_products/amino_acids_and_peptides/leinamycin.yaml, which is generated from the committed inventories. Neither is edited by hand.