leucinostatin A

naturalproductmech:mibig-5ff806da31 MINTED SEEDED cytotoxic

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	FOAIGCPESMNWQP-WCWDXBQESA-N
SMILES	CCC(C)/C=C/C(=O)N1CC(CC1C(=O)NC(CC(C)CC(CC(=O)CC)O)C(=O)NC(C(C(C)C)O)C(=O)NC(C)(C)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)NCCC(=O)NC(C)CN(C)C)C
Stereochemistry	undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-references	pubchem:5477807

Filing pathway

Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Purpureocillium lilacinum NCBITaxon:33203	SOURCE_ASSERTION	mibig:BGC0001358	DOI:10.3390/molecules25215077

Occurrences 2

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Paecilomyces NCBITaxon:33202	LOTUS	DOI:10.7164/ANTIBIOTICS.35.1231
Purpureocillium lilacinum NCBITaxon:33203	LOTUS	DOI:10.1371/JOURNAL.PPAT.1005685

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0001358	Purpureocillium lilacinum NCBITaxon:33203	CLUSTER_UNSTATED	genbank:LSBH01000002.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 25

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Explore across X-Mech

AntibioticMech (leucinostatin A) ↗ MediaIngredientMech (naturalproductmech:mibig-5ff806da31) ↗ TaxonMech: Purpureocillium lilacinum (NCBITaxon:33203) ↗ PathwayMech (mibig:BGC0001358) ↗

Provenance

Source concept	Source	Version
BGC0001358	MIBIG	4

This page is generated from data/natural_products/amino_acids_and_peptides/leucinostatin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.

Assay	Result	Target enzyme	Source detail
NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line	ACTIVE	Not recorded	pubchem.aid:19 assay NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line evidence reference pubchem.aid:19 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 19, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the BT-549 Breast cell line	ACTIVE	Not recorded	pubchem.aid:89 assay NCI human tumor cell line growth inhibition assay. Data for the BT-549 Breast cell line evidence reference pubchem.aid:89 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 89, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Leukemia cell line	ACTIVE	Not recorded	pubchem.aid:119 assay NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Leukemia cell line evidence reference pubchem.aid:119 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 119, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the COLO 205 Colon cell line	ACTIVE	Not recorded	pubchem.aid:67 assay NCI human tumor cell line growth inhibition assay. Data for the COLO 205 Colon cell line evidence reference pubchem.aid:67 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 67, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line	ACTIVE	Not recorded	pubchem.aid:43 assay NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line evidence reference pubchem.aid:43 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 43, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the EKVX Non-Small Cell Lung cell line	ACTIVE	Not recorded	pubchem.aid:21 assay NCI human tumor cell line growth inhibition assay. Data for the EKVX Non-Small Cell Lung cell line evidence reference pubchem.aid:21 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 21, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HCC-2998 Colon cell line	ACTIVE	Not recorded	pubchem.aid:77 assay NCI human tumor cell line growth inhibition assay. Data for the HCC-2998 Colon cell line evidence reference pubchem.aid:77 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 77, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HCT-116 Colon cell line	ACTIVE	Not recorded	pubchem.aid:79 assay NCI human tumor cell line growth inhibition assay. Data for the HCT-116 Colon cell line evidence reference pubchem.aid:79 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 79, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line	ACTIVE	Not recorded	pubchem.aid:125 assay NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line evidence reference pubchem.aid:125 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 125, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HOP-62 Non-Small Cell Lung cell line	ACTIVE	Not recorded	pubchem.aid:9 assay NCI human tumor cell line growth inhibition assay. Data for the HOP-62 Non-Small Cell Lung cell line evidence reference pubchem.aid:9 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 9, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line	ACTIVE	Not recorded	pubchem.aid:13 assay NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line evidence reference pubchem.aid:13 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 13, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HS 578T Breast cell line	ACTIVE	Not recorded	pubchem.aid:97 assay NCI human tumor cell line growth inhibition assay. Data for the HS 578T Breast cell line evidence reference pubchem.aid:97 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 97, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HT29 Colon cell line	ACTIVE	Not recorded	pubchem.aid:65 assay NCI human tumor cell line growth inhibition assay. Data for the HT29 Colon cell line evidence reference pubchem.aid:65 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 65, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Ovarian cell line	ACTIVE	Not recorded	pubchem.aid:101 assay NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Ovarian cell line evidence reference pubchem.aid:101 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 101, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell line	ACTIVE	Not recorded	pubchem.aid:121 assay NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell line evidence reference pubchem.aid:121 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 121, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the KM12 Colon cell line	ACTIVE	Not recorded	pubchem.aid:73 assay NCI human tumor cell line growth inhibition assay. Data for the KM12 Colon cell line evidence reference pubchem.aid:73 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 73, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the LOX IMVI Melanoma cell line	ACTIVE	Not recorded	pubchem.aid:23 assay NCI human tumor cell line growth inhibition assay. Data for the LOX IMVI Melanoma cell line evidence reference pubchem.aid:23 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 23, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line	ACTIVE	Not recorded	pubchem.aid:29 assay NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line evidence reference pubchem.aid:29 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 29, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the MCF7 Breast cell line	ACTIVE	Not recorded	pubchem.aid:83 assay NCI human tumor cell line growth inhibition assay. Data for the MCF7 Breast cell line evidence reference pubchem.aid:83 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 83, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the MDA-MB-231/ATCC Breast cell line	ACTIVE	Not recorded	pubchem.aid:95 assay NCI human tumor cell line growth inhibition assay. Data for the MDA-MB-231/ATCC Breast cell line evidence reference pubchem.aid:95 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 95, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the MDA-MB-435 Melanoma cell line	ACTIVE	Not recorded	pubchem.aid:85 assay NCI human tumor cell line growth inhibition assay. Data for the MDA-MB-435 Melanoma cell line evidence reference pubchem.aid:85 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 85, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line	ACTIVE	Not recorded	pubchem.aid:87 assay NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line evidence reference pubchem.aid:87 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 87, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the MOLT-4 Leukemia cell line	ACTIVE	Not recorded	pubchem.aid:123 assay NCI human tumor cell line growth inhibition assay. Data for the MOLT-4 Leukemia cell line evidence reference pubchem.aid:123 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 123, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the NCI-H226 Non-Small Cell Lung cell line	ACTIVE	Not recorded	pubchem.aid:3 assay NCI human tumor cell line growth inhibition assay. Data for the NCI-H226 Non-Small Cell Lung cell line evidence reference pubchem.aid:3 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 3, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line	ACTIVE	Not recorded	pubchem.aid:1 assay NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line evidence reference pubchem.aid:1 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC notes 26 further PubChem assay results are in data/raw/pubchem_bioassay.tsv but not written here.