malacidin A
CHEBI:140173 EXACT SEEDED antibacterial
A homodetic cyclic peptide containing a 28-membered ring and consisting of 3-methyl-N-[(2E,4Z)-8-methylnona-2,4-dienoyl]-L-α-aspartyl, (2S)-2,3-diaminobutanoyl, D-valyl, L-lysyl, 3-hydroxy-L-α-aspartyl, L-α-aspartyl, glycyl, 3-methyl-D-α-aspartyl, L-valyl, and (4R)-methyl-L-proline joined in sequence and cyclised by condensation of the β-amino group of the 2,3-diaminobutanoyl residue with the carboxy group of the 4-methylproline residue.
Structure
| Standard InChIKey | USNOUEMKNKRWQT-ORRWAHHJSA-N |
|---|---|
| SMILES | C[C@@H]1C[C@H]2C(=O)NC([C@@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C(=O)N[C@H](C(=O)N2C1)C(C)C)C(C)C(=O)O)CC(=O)O)C(C(=O)O)O)CCCCN)C(C)C)NC(=O)[C@H](C(C)C(=O)O)NC(=O)/C=C/C=C\CCC(C)C)C |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | pubchem:132282518 |
Filing pathway
Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.
Producer organisms 0
None. The compound has a characterized gene cluster whose host NCBI does not name, which for an uncultured symbiont is the honest state — see the discussion below.
Occurrences 0
None cited.
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001448 | not named | CLUSTER_DEMONSTRATED | genbank:KY654519.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Elsewhere in the fleet
- AntibioticMech — CHEBI:140173 (same structure, same inchikey)
Open questions 1
unnamed-producer — No producer claim is written from BGC0001448, which gives NCBITaxon:77133 (uncultured bacterium — shared by every unplaced bacterium), because the taxon names no single organism. The cluster is kept: a characterized locus is an origin assertion whether or not its host has a name, and for a compound from an uncultured symbiont that is the honest state. Name the producer if the primary literature does.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001448 | MIBIG | 5 |
| CHEBI:140173 | CHEBI | 3-star |
This page is generated from data/natural_products/amino_acids_and_peptides/malacidin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.