myxochromide A

naturalproductmech:mibig-82041a5d45 MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	NDLATPRQLJTXJX-OBQOMHFNSA-N
SMILES	CN([C@H]1[C@@H](C)OC(=O)CC[C@H](NC(=O)[C@H](NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC1=O)C)C)C(=O)N)C(=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C
Stereochemistry	fully defined

Filing pathway

Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, from MIBiG.

Producer organisms 4

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Myxococcus xanthus DK 1622 NCBITaxon:246197	BGC_CHARACTERIZED	mibig:BGC0001425	PMID:28128551
Myxococcus xanthus Strain: DK897 NCBITaxon:34	SOURCE_ASSERTION	mibig:BGC0001426	PMID:28128551, https://www.ncbi.nlm.nih.gov/nuccore/KX622596.1 reference PMID:28128551 evidence type DATABASE_ASSERTION notes MIBiG BGC0001426 entry version 4; citation taken from the entry level reference https://www.ncbi.nlm.nih.gov/nuccore/KX622596.1 evidence type CURATOR_INFERENCE notes Strain context: DK897. The KX622596.1 GenBank source feature identifies DK897. This qualifies the deposited locus, not exact myxochromide congener production; the chemical identity conflict remains open in issue #924. No taxon or evidence grade changes. See issue #926. Taxon identity and evidence grade are unchanged; this is not a species-wide experiment. MIBiG source row BGC0001426:1; SHA256 06dc280056bd2cbaff201e2da61c3a6215c47482780bf93d91a0f38dbf9071e4. Curator: codex; date: 2026-10-13.
Myxococcus xanthus Strain: A47 NCBITaxon:34	SOURCE_ASSERTION	mibig:BGC0001427	PMID:28128551, https://www.ncbi.nlm.nih.gov/nuccore/KX622597.1 reference PMID:28128551 evidence type DATABASE_ASSERTION notes MIBiG BGC0001427 entry version 4; citation taken from the entry level reference https://www.ncbi.nlm.nih.gov/nuccore/KX622597.1 evidence type CURATOR_INFERENCE notes Strain context: A47. The KX622597.1 GenBank source feature identifies A47. This qualifies the deposited locus, not exact myxochromide congener production; the chemical identity conflict remains open in issue #924. No taxon or evidence grade changes. See issue #926. Taxon identity and evidence grade are unchanged; this is not a species-wide experiment. MIBiG source row BGC0001427:1; SHA256 4d6c99aeedb287e6fa4d8f4c349258c47c6a545a35498afbe7f9ec4fba4f7194. Curator: codex; date: 2026-10-13.
Myxococcus xanthus Strain: Mx48 NCBITaxon:34	SOURCE_ASSERTION	mibig:BGC0001428	PMID:28128551, https://www.ncbi.nlm.nih.gov/nuccore/KX622598.1 reference PMID:28128551 evidence type DATABASE_ASSERTION notes MIBiG BGC0001428 entry version 4; citation taken from the entry level reference https://www.ncbi.nlm.nih.gov/nuccore/KX622598.1 evidence type CURATOR_INFERENCE notes Strain context: Mx48. The KX622598.1 GenBank source feature identifies Mx48. This qualifies the deposited locus, not exact myxochromide congener production; the chemical identity conflict remains open in issue #924. No taxon or evidence grade changes. See issue #926. Taxon identity and evidence grade are unchanged; this is not a species-wide experiment. MIBiG source row BGC0001428:1; SHA256 399c5a981f1674e3178e597f0b409504c57c16f089859ef61e130b2ddbae34e6. Curator: codex; date: 2026-10-13.

Occurrences 0

None cited.

Biosynthetic gene clusters 4

Accession	Host	Locus evidence	Genome
mibig:BGC0001425	Myxococcus xanthus DK 1622 NCBITaxon:246197	CLUSTER_DEMONSTRATED	genbank:KX622595.1
mibig:BGC0001426	Myxococcus xanthus NCBITaxon:34	CLUSTER_UNSTATED	genbank:KX622596.1
mibig:BGC0001427	Myxococcus xanthus NCBITaxon:34	CLUSTER_UNSTATED	genbank:KX622597.1
mibig:BGC0001428	Myxococcus xanthus NCBITaxon:34	CLUSTER_UNSTATED	genbank:KX622598.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Explore across X-Mech

AntibioticMech (myxochromide A) ↗ MediaIngredientMech (naturalproductmech:mibig-82041a5d45) ↗ TaxonMech: Myxococcus xanthus DK 1622 (NCBITaxon:246197) ↗ TaxonMech: Myxococcus xanthus (NCBITaxon:34) ↗ TaxonMech: Myxococcus xanthus (NCBITaxon:34) ↗ TaxonMech: Myxococcus xanthus (NCBITaxon:34) ↗ PathwayMech (mibig:BGC0001425) ↗ PathwayMech (mibig:BGC0001426) ↗ PathwayMech (mibig:BGC0001427) ↗

Open questions 2

shared-structure — This structure is reported by more than one MIBiG entry: BGC0001425, BGC0001426, BGC0001427, BGC0001428. Confirm they describe the same compound rather than an upstream cross-reference error.

curator-myxochromide-a-core-identity — Does the imported C45 graph represent the experimentally established product of each of BGC0001425-1428?

Provenance

Source concept	Source	Version
BGC0001425	MIBIG	4
BGC0001426	MIBIG	4
BGC0001427	MIBIG	4
BGC0001428	MIBIG	4

This page is generated from data/natural_products/amino_acids_and_peptides/myxochromide-a.yaml, which is generated from the committed inventories. Neither is edited by hand.