N-acetyltryptophan

CHEBI:70976 EXACT SEEDED

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

An N-acetylamino acid that is the N-acetyl derivative of tryptophan.

Structure

Standard InChIKey	DZTHIGRZJZPRDV-UHFFFAOYSA-N
SMILES	CC(=O)NC(CC1=CNC2=C1C=CC=C2)C(O)=O
Stereochemistry	undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-references	npatlas:NPA015473

Filing pathway

Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Aspergillus nidulans FGSC A4 NCBITaxon:227321	SOURCE_ASSERTION	mibig:BGC0001679	DOI:10.1038/s41598-021-88693-8

Occurrences 4

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Bacillus pumilus NCBITaxon:1408	LOTUS	DOI:10.1016/S0378-1097(02)01065-0
Aspergillus nidulans NCBITaxon:162425	LOTUS	DOI:10.1016/J.FGB.2017.01.006
Penicillium commune NCBITaxon:36653	LOTUS	DOI:10.3390/MOLECULES15053270
Glycine max NCBITaxon:3847	LOTUS	DOI:10.1111/TPJ.12607

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0001679	Aspergillus nidulans FGSC A4 NCBITaxon:227321	CLUSTER_UNSTATED	genbank:BN001303.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Molecular targets 1

Target	Target organism	Measurement	Evidence
Tryptophanase PROTEIN BINDS UniProtKB:P0A853	Escherichia coli (strain K12) NCBITaxon:83333	KI 4.8e+07 nM	PMID:18608755 reference PMID:18608755 evidence type DATABASE_ASSERTION notes BindingDB own-curated affinity; measured at pH 7.8000, 25.00 C C; qualifier EQUAL.

Explore across X-Mech

AntibioticMech (N-acetyltryptophan) ↗ MediaIngredientMech (CHEBI:70976) ↗ TaxonMech: Aspergillus nidulans FGSC A4 (NCBITaxon:227321) ↗ PathwayMech (mibig:BGC0001679) ↗

Provenance

Source concept	Source	Version
BGC0001679	MIBIG	3
CHEBI:70976	CHEBI	3-star

This page is generated from data/natural_products/amino_acids_and_peptides/n-acetyltryptophan.yaml, which is generated from the committed inventories. Neither is edited by hand.