NaturalProductMech

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polymyxin

naturalproductmech:mibig-2f5f003d07 MINTED SEEDED enzyme inhibitor

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.
What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKeyHFMDLUQUEXNBOP-UHFFFAOYSA-N
SMILESCCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC2=CC=CC=C2)CC(C)C)CCN)CCN)C(C)O.OS(=O)(=O)O
Stereochemistry undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-referencespubchem:5702105

Filing pathway

Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

TaxonBasisClusterEvidence
Paenibacillus polymyxa
NCBITaxon:1406		 SOURCE_ASSERTION mibig:BGC0000408 PMID:19304848

Occurrences 0

None cited.

Biosynthetic gene clusters 1

AccessionHostLocus evidenceGenome
mibig:BGC0000408 Paenibacillus polymyxa
NCBITaxon:1406 		CLUSTER_UNSTATED genbank:EU371992.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

PRODUCERS & OCCURRENCE 1 producer (0 causal) 0 cited occurrences BIOSYNTHETIC LOCUS 1 gene cluster 0 curated pathway steps NATURAL PRODUCT polymyxin naturalproductmech:mibig-2f5f003d07 Amino acids and peptides TARGETS & BIOACTIVITY 0 molecular targets 19 bioactivities · 0 graphs

Bioactivities 19

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

AssayResultTarget enzymeSource detail
A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells.OTHER 16.7889 uM; NOT_DETERMINEDNot recorded
pubchem.aid:624296
assay
A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells.
evidence
  • reference
    pubchem.aid:624296
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 624296, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_056979 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
16.7889
units
uM
Confirmation of Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived PeptideOTHER 10 uM; ACTIVENot recorded
pubchem.aid:2783
assay
Confirmation of Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide
evidence
  • reference
    pubchem.aid:2783
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2783, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession NP_000235 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
ACTIVE
measurement type
OTHER
value
10.0
units
uM
Confirmation of Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived PeptideOTHER 10 uM; ACTIVENot recorded
pubchem.aid:2783
assay
Confirmation of Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide
evidence
  • reference
    pubchem.aid:2783
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2783, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession NP_005924 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
ACTIVE
measurement type
OTHER
value
10.0
units
uM
Confirmation of Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant PeptideOTHER 7.0795 uM; ACTIVENot recorded
pubchem.aid:2782
assay
Confirmation of Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide
evidence
  • reference
    pubchem.aid:2782
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2782, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession NP_000235 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
ACTIVE
measurement type
OTHER
value
7.0795
units
uM
Confirmation of Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant PeptideOTHER 7.0795 uM; ACTIVENot recorded
pubchem.aid:2782
assay
Confirmation of Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide
evidence
  • reference
    pubchem.aid:2782
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2782, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession NP_005924 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
ACTIVE
measurement type
OTHER
value
7.0795
units
uM
Confirmation qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)OTHER 2.8184 uM; ACTIVENot recorded
pubchem.aid:2708
assay
Confirmation qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)
evidence
  • reference
    pubchem.aid:2708
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2708, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession 2WWY_A was left ungrounded because PubChem did not provide a UniProtKB accession.
call
ACTIVE
measurement type
OTHER
value
2.8184
units
uM
activity class
ENZYME_INHIBITOR
Counterscreen for BLMA Inhibitors: ADP Fluorescence Polarization Displacement AssayOTHER 4.4668 uM; NOT_DETERMINEDNot recorded
pubchem.aid:2712
assay
Counterscreen for BLMA Inhibitors: ADP Fluorescence Polarization Displacement Assay
evidence
  • reference
    pubchem.aid:2712
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2712, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
4.4668
units
uM
Counterscreen for RECQ1 Inhibitors: ADP Fluorescence Polarization Displacement AssayOTHER 4.4668 uM; NOT_DETERMINEDNot recorded
pubchem.aid:2711
assay
Counterscreen for RECQ1 Inhibitors: ADP Fluorescence Polarization Displacement Assay
evidence
  • reference
    pubchem.aid:2711
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2711, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
4.4668
units
uM
Inhibitors of USP1/UAF1: Pilot qHTSOTHER 50.1187 uM; ACTIVENot recorded
pubchem.aid:504865
assay
Inhibitors of USP1/UAF1: Pilot qHTS
evidence
  • reference
    pubchem.aid:504865
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 504865, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession AAH18745 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
ACTIVE
measurement type
OTHER
value
50.1187
units
uM
activity class
ENZYME_INHIBITOR
S16 Schwann cell viability assay (CellTiter-Glo assay)OTHER 0.0102 uM; NOT_DETERMINEDNot recorded
pubchem.aid:624031
assay
S16 Schwann cell viability assay (CellTiter-Glo assay)
evidence
  • reference
    pubchem.aid:624031
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 624031, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
0.0102
units
uM
qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid LeukemiaOTHER 4.4668 uM; NOT_DETERMINEDNot recorded
pubchem.aid:1477
assay
qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia
evidence
  • reference
    pubchem.aid:1477
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1477, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
4.4668
units
uM
qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase)OTHER 8.9125 uM; NOT_DETERMINEDNot recorded
pubchem.aid:1452
assay
qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase)
evidence
  • reference
    pubchem.aid:1452
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1452, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_000688 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
8.9125
units
uM
qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2)OTHER 0.631 uM; INACTIVEUniProtKB:O15296
pubchem.aid:881
assay
qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2)
evidence
  • reference
    pubchem.aid:881
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 881, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency.
call
INACTIVE
measurement type
OTHER
value
0.631
units
uM
target enzyme
UniProtKB:O15296
qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase)OTHER 28.1838 uM; ACTIVENot recorded
pubchem.aid:1490
assay
qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase)
evidence
  • reference
    pubchem.aid:1490
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1490, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession AAG24257 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
ACTIVE
measurement type
OTHER
value
28.1838
units
uM
activity class
ENZYME_INHIBITOR
qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM)OTHER 7.9433 uM; ACTIVENot recorded
pubchem.aid:2528
assay
qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM)
evidence
  • reference
    pubchem.aid:2528
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2528, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession NP_000048 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
ACTIVE
measurement type
OTHER
value
7.9433
units
uM
activity class
ENZYME_INHIBITOR
qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)OTHER 5.0119 uM; ACTIVENot recorded
pubchem.aid:2549
assay
qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)
evidence
  • reference
    pubchem.aid:2549
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2549, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession 2WWY_A was left ungrounded because PubChem did not provide a UniProtKB accession.
call
ACTIVE
measurement type
OTHER
value
5.0119
units
uM
activity class
ENZYME_INHIBITOR
qHTS Assay for Lipid Storage ModulatorsOTHER 11.2202 uM; NOT_DETERMINEDNot recorded
pubchem.aid:1519
assay
qHTS Assay for Lipid Storage Modulators
evidence
  • reference
    pubchem.aid:1519
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1519, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
11.2202
units
uM
qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase: hit validationOTHER 3.9811 uM; NOT_DETERMINEDNot recorded
pubchem.aid:492961
assay
qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase: hit validation
evidence
  • reference
    pubchem.aid:492961
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 492961, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession XP_843920 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
3.9811
units
uM
A screen for compounds that inhibit replication of Vibrio cholerae chromosome IIACTIVENot recorded
pubchem.aid:504770
assay
A screen for compounds that inhibit replication of Vibrio cholerae chromosome II
evidence
  • reference
    pubchem.aid:504770
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 504770, deposited by ICCB-Longwood/NSRB Screening Facility, Harvard Medical School; assay type Other. Target accession AAF95916 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
ACTIVE

Explore across X-Mech

AntibioticMech (polymyxin) ↗ MediaIngredientMech (naturalproductmech:mibig-2f5f003d07) ↗ TaxonMech: Paenibacillus polymyxa (NCBITaxon:1406) ↗ PathwayMech (mibig:BGC0000408) ↗

Provenance

Source conceptSourceVersion
BGC0000408MIBIG5

This page is generated from data/natural_products/amino_acids_and_peptides/polymyxin.yaml, which is generated from the committed inventories. Neither is edited by hand.