polymyxin
naturalproductmech:mibig-2f5f003d07 MINTED SEEDED enzyme inhibitor
Structure
| Standard InChIKey | HFMDLUQUEXNBOP-UHFFFAOYSA-N |
|---|---|
| SMILES | CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC2=CC=CC=C2)CC(C)C)CCN)CCN)C(C)O.OS(=O)(=O)O |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | pubchem:5702105 |
Filing pathway
Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Paenibacillus polymyxa NCBITaxon:1406 |
SOURCE_ASSERTION | mibig:BGC0000408 | PMID:19304848 |
Occurrences 0
None cited.
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000408 | Paenibacillus polymyxa NCBITaxon:1406 |
CLUSTER_UNSTATED | genbank:EU371992.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 19
| Assay | Result | Reference |
|---|---|---|
| A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. | 16.7889 uM | pubchem.aid:624296 |
| Confirmation of Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide | 10 uM | pubchem.aid:2783 |
| Confirmation of Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide | 10 uM | pubchem.aid:2783 |
| Confirmation of Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide | 7.0795 uM | pubchem.aid:2782 |
| Confirmation of Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide | 7.0795 uM | pubchem.aid:2782 |
| Confirmation qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) | 2.8184 uM | pubchem.aid:2708 |
| Counterscreen for BLMA Inhibitors: ADP Fluorescence Polarization Displacement Assay | 4.4668 uM | pubchem.aid:2712 |
| Counterscreen for RECQ1 Inhibitors: ADP Fluorescence Polarization Displacement Assay | 4.4668 uM | pubchem.aid:2711 |
| Inhibitors of USP1/UAF1: Pilot qHTS | 50.1187 uM | pubchem.aid:504865 |
| S16 Schwann cell viability assay (CellTiter-Glo assay) | 0.0102 uM | pubchem.aid:624031 |
| qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia | 4.4668 uM | pubchem.aid:1477 |
| qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase) | 8.9125 uM | pubchem.aid:1452 |
| qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2) | 0.631 uM | pubchem.aid:881 |
| qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) | 28.1838 uM | pubchem.aid:1490 |
| qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) | 7.9433 uM | pubchem.aid:2528 |
| qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) | 5.0119 uM | pubchem.aid:2549 |
| qHTS Assay for Lipid Storage Modulators | 11.2202 uM | pubchem.aid:1519 |
| qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase: hit validation | 3.9811 uM | pubchem.aid:492961 |
| A screen for compounds that inhibit replication of Vibrio cholerae chromosome II | ACTIVE | pubchem.aid:504770 |
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000408 | MIBIG | 5 |
This page is generated from data/natural_products/amino_acids_and_peptides/polymyxin.yaml, which is generated from the committed inventories. Neither is edited by hand.