precolibactin 1489
naturalproductmech:mibig-c10619b615 MINTED SEEDED
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
Structure
| Standard InChIKey | ABGXHXAPJINIRD-DUFVVOHASA-N |
|---|---|
| SMILES | C(CCCCCCCCCCCC)C(=O)N[C@H](CC(=O)N)C(N[C@H](CCC(CC(=O)N[C@]1(CC1)C(=O)CC(=O)NCC(=O)c1csc(C2C3(O)c4csc(CNC(=O)CC(=O)[C@]5(CC5)NC(=O)CC(CC[C@H](C)NC(=O)[C@@H](CC(=O)N)NC(=O)CCCCCCCCCCCCC)(O3)N=2)n4)n1)=O)C)=O |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
Filing pathway
Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Escherichia coli NCBITaxon:562 |
BGC_CHARACTERIZED | mibig:BGC0000972 | PMID:16902142 |
Occurrences 0
None cited.
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000972 | Escherichia coli NCBITaxon:562 |
CLUSTER_DEMONSTRATED | genbank:AM229678.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
Explore across X-Mech
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000972 | MIBIG | 5 |
This page is generated from data/natural_products/amino_acids_and_peptides/precolibactin-1489.yaml, which is generated from the committed inventories. Neither is edited by hand.