Ristocetin A
CHEBI:85129 EXACT SEEDED antibacterial
A heterodetic cyclic peptide that is produced by species of Amycolatopsis and Nocardia.
Structure
| Standard InChIKey | VUOPFFVAZTUEGW-FBMDODLCSA-N |
|---|---|
| SMILES | C[C@H]1[C@@H]([C@@H](C[C@H](O1)O[C@H]2[C@H]3C(=O)N[C@@H](C4=CC(=CC(=C4C5=C(C=CC(=C5)[C@H](C(=O)N3)NC(=O)[C@H]6C7=CC(=C(C(=C7)OC8=CC=C2C=C8)O[C@H]9[C@@H]([C@H]([C@@H]([C@H](O9)COC1[C@@H]([C@@H]([C@H]([C@@H](O1)C)O)O)O)O)O)O[C@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)CO)O)O)O[C@H]1[C@H]([C@@H]([C@@H](CO1)O)O)O)OC1=CC=C(C=C1)[C@H]([C@@H]1C(=O)N[C@@H](C2=CC(=C(C(=C2)O)C)OC2=C(C=CC(=C2)[C@H](C(=O)N1)N)O)C(=O)N6)O)O)O[C@H]1[C@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)O)C(=O)OC)N)O |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | pubchem:16131418, npatlas:NPA020115 |
Filing pathway
Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Amycolatopsis lurida NCBITaxon:31959 |
SOURCE_ASSERTION | mibig:BGC0000418 | DOI:10.1128/aac.03512-14 |
Occurrences 3
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Amycolatopsis lurida NCBITaxon:1460371 |
CHEBI | PMID:25323720 |
| Nocardia NCBITaxon:1817 |
LOTUS | DOI:10.1039/C39790000906 |
| Amycolatopsis sp. NCBITaxon:37632 |
CHEBI | PMID:25359910 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000418 | Amycolatopsis lurida NCBITaxon:31959 |
CLUSTER_UNSTATED | genbank:KJ364518.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Elsewhere in the fleet
- AntibioticMech — CHEBI:85129 (same structure, same inchikey)
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000418 | MIBIG | 5 |
| CHEBI:85129 | CHEBI | 3-star |
This page is generated from data/natural_products/amino_acids_and_peptides/ristocetin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.