streptide

naturalproductmech:mibig-81e97b6b8c MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	UEOXFKPVURAKAA-RMYJOMHKSA-N
SMILES	C[C@@H](C(=O)N[C@H]1[C@H](C2=CC=CC3=C2NC=C3C[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC1=O)CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(=O)O)CCCN)N
Stereochemistry	fully defined
Cross-references	pubchem:91666311

Filing pathway

Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is ribosomal, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptococcus thermophilus LMD-9 NCBITaxon:322159	SOURCE_ASSERTION	mibig:BGC0001209	PMID:25901822

Occurrences 0

None cited.

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0001209	Streptococcus thermophilus LMD-9 NCBITaxon:322159	CLUSTER_UNSTATED	genbank:CP000419.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Causal graph — biosynthesis 2 nodes, 1 edge

Native-reference identity only for Streptococcus thermophilus LMD-9/taxon 322159/CP000419.1. Placement in this owner is curator-inferred from the shared BGC0001209 context, not proof of conversion to its exact mature structure. StrB is the MITE-mapped name for the deposited STER_1356 protein. No assay construct, enzyme activity, precursor processing, reaction order or physical complex is asserted. Source reaction models remain withheld under https://github.com/CultureBotAI/NaturalProductMech/issues/702 because listed product and literal reaction SMARTS disagree in stereochemistry. MITE cites DOI:10.1038/nchem.2237; that paper was inaccessible when attempted on 2026-10-08 and retrieval stopped.

Subject	Predicate	Object	Notes	Evidence
STER_1356 CDS (CP000419.1)	encodes the native protein reference	StrB (LMD-9 native-reference example)	1260174..1261493 reverse strand; 1320-nt complete CDS including stop, 439 residues. Reference identity does not validate a reaction model.	https://www.ncbi.nlm.nih.gov/nuccore/CP000419.1 https://www.ncbi.nlm.nih.gov/protein/ABJ66529.1 https://rest.uniprot.org/uniparc/UPI0000E5643D.json https://github.com/mite-standard/mite_data/blob/6eacd913b2036376031072f69cbb33908f132998/mite_data/data/MITE0000439.json reference https://www.ncbi.nlm.nih.gov/nuccore/CP000419.1 evidence type DATABASE_ASSERTION retrieved on 2026-10-08 snippet /locus_tag="STER_1356" notes Deposited CDS names ABJ66529.1, codon_start 1 and translation table 11. The inspected 3,513-bp interval is CP000419.1:1259086..1262598, not the whole genome. Source names LMD-9/taxon 322159. The annotation is not an assay and does not itself name strB. reference https://www.ncbi.nlm.nih.gov/protein/ABJ66529.1 evidence type DATABASE_ASSERTION retrieved on 2026-10-08 notes GenPept ABJ66529.1 identifies the 439-residue STER_1356 protein from Streptococcus thermophilus LMD-9. Its coded_by gives complement(CP000419.1:1260174..1261493). The versioned native protein, not a family, other-strain homolog or verified historical assay construct, grounds this node. reference https://rest.uniprot.org/uniparc/UPI0000E5643D.json evidence type CURATOR_INFERENCE retrieved on 2026-10-08 notes Complete-CDS-aware translation, deposited translation, GenPept and UniParc agree over all 439 residues. Direct active EMBL accession/version, locus tag and taxon agree. All 19 UniProtKB cross-references in the inspected archive are inactive, including native Q03JU3; no current UniProtKB example is established. A shared sequence archive does not transfer other-strain experiments or supply independent reaction evidence. reference https://github.com/mite-standard/mite_data/blob/6eacd913b2036376031072f69cbb33908f132998/mite_data/data/MITE0000439.json evidence type DATABASE_ASSERTION retrieved on 2026-10-08 notes Active MITE0000439 version 1 maps its StrB name to ABJ66529.1, UPI0000E5643D and BGC0001209. Its uniprot field contains a UniParc ID. This citation supports source mapping only. Reaction models remain withheld under https://github.com/CultureBotAI/NaturalProductMech/issues/702; no primary reaction experiment or precursor processing is adopted.

Every edge carries its own citation; an uncited edge is refused by the corpus tests.

Causal graph — biosynthesis 2 nodes, 1 edge

Native unmodified precursor reference only for STER_1357 in Streptococcus thermophilus LMD-9/taxon 322159/CP000419.1. The StrA alias is curator-inferred from the exact neutral native precursor model matching the MITE substrate that its narrative calls the strA product. The deposit itself says Predicted protein and not curated, without a strA gene qualifier. Owner placement is inferred from BGC0001209, not proof of conversion to the exact mature structure. The 30-residue reference is not the mature nine-residue compound or a crosslinked peptide state. No assay construct, processing assignment, physical complex or current UniProtKB example is adopted. Reaction models remain withheld under https://github.com/CultureBotAI/NaturalProductMech/issues/702. MITE cites DOI:10.1038/nchem.2237; that paper was inaccessible when attempted on 2026-10-08 and retrieval stopped.

Subject	Predicate	Object	Notes	Evidence
STER_1357 CDS (CP000419.1)	encodes the native precursor reference	STER_1357 (StrA-mapped native precursor)	1261563..1261655 reverse strand; 93-nt complete CDS including stop, 30 residues. Complete-CDS-aware translation, deposited translation and independent GenPept sequence agree. The StrA alias mapping does not validate a reaction or assay construct.	https://www.ncbi.nlm.nih.gov/nuccore/CP000419.1 https://www.ncbi.nlm.nih.gov/protein/ABJ66530.1 https://github.com/mite-standard/mite_data/blob/6eacd913b2036376031072f69cbb33908f132998/mite_data/data/MITE0000439.json https://github.com/mite-standard/mite_data/blob/6eacd913b2036376031072f69cbb33908f132998/mite_data/data/MITE0000439.json https://rest.uniprot.org/uniparc/UPI0000E5643E.json reference https://www.ncbi.nlm.nih.gov/nuccore/CP000419.1 evidence type DATABASE_ASSERTION retrieved on 2026-10-08 snippet /locus_tag="STER_1357" notes Deposited CDS names ABJ66530.1, codon_start 1 and translation table 11. The inspected interval is CP000419.1:1259086..1262598, 3,513 bp, not the entire genome. The annotation is not an experiment. reference https://www.ncbi.nlm.nih.gov/protein/ABJ66530.1 evidence type DATABASE_ASSERTION retrieved on 2026-10-08 notes GenPept ABJ66530.1 is a 30-residue Predicted protein from LMD-9/taxon 322159, locus STER_1357. coded_by is complement(CP000419.1:1261563..1261655), with note not curated. The versioned native protein, not an arbitrary homolog, grounds the node. No UniProtKB accession was examined or selected for this precursor. reference https://github.com/mite-standard/mite_data/blob/6eacd913b2036376031072f69cbb33908f132998/mite_data/data/MITE0000439.json evidence type DATABASE_ASSERTION retrieved on 2026-10-08 notes Active MITE0000439 version 1 names the strA product as a 30mer precursor substrate. Its crosslinked product is an intermediate; further processing is described as likely. Neither the model nor those statements identify the unmodified precursor with mature streptide. reference https://github.com/mite-standard/mite_data/blob/6eacd913b2036376031072f69cbb33908f132998/mite_data/data/MITE0000439.json evidence type CURATOR_INFERENCE retrieved on 2026-10-08 notes RDKit 2026.03.5 gives the neutral unmodified model built from the deposited 30-residue sequence and the literal MITE substrate the same full key XOBXWZPMBNJSOG-KFBHTRSUSA-N. This supports the StrA alias mapping, not a historical assay construct or modified peptide identity. The mature owner key UEOXFKPVURAKAA-RMYJOMHKSA-N differs. Source reaction stereochemistry remains unresolved under issue 702. reference https://rest.uniprot.org/uniparc/UPI0000E5643E.json evidence type DATABASE_ASSERTION notes UniParc UPI0000E5643E (30 aa) links active EMBL ABJ66530.1 (Streptococcus thermophilus ATCC BAA-491 / LMD-9, taxon 322159, gene STER_1357) and inactive UniProtKB/TrEMBL entries Q03JU2 (STER_1357), F8LYE5 (STH8232_1610) and W7V534 (Y016_10450), with zero active UniProtKB cross-references. retrieved on 2026-10-30

Every edge carries its own citation; an uncited edge is refused by the corpus tests.

Explore across X-Mech

AntibioticMech (streptide) ↗ MediaIngredientMech (naturalproductmech:mibig-81e97b6b8c) ↗ TaxonMech: Streptococcus thermophilus LMD-9 (NCBITaxon:322159) ↗ PathwayMech (mibig:BGC0001209) ↗

Provenance

Source concept	Source	Version
BGC0001209	MIBIG	3

This page is generated from data/natural_products/amino_acids_and_peptides/streptide.yaml, which is generated from the committed inventories. Neither is edited by hand.