tallysomycin A

naturalproductmech:mibig-31266dfbb0 MINTED SEEDED cytotoxic

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	VUPBDWQPEOWRQP-UHFFFAOYSA-N
SMILES	CC1C(C(C(C(O1)OC(C(C2=NC(=CS2)C3=NC(=CS3)C(=O)NCCCC(CC(=O)NCCCNCCCCN)N)O)NC(=O)C(C(C)O)NC(=O)CC(C(C)NC(=O)C(C(C4=CN=CN4)OC5C(C(C(C(O5)CO)O)O)OC6C(C(C(C(O6)CO)O)OC(=O)N)O)NC(=O)C7=C(C(=NC(=N7)C(CC(=O)N)NCC(C(=O)N)N)N)C)O)O)O)N
Stereochemistry	undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-references	pubchem:430602

Filing pathway

Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, saccharide, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptoalloteichus hindustanus NCBITaxon:2017	BGC_CHARACTERIZED	mibig:BGC0001048	PMID:17216057

Occurrences 1

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Streptoalloteichus hindustanus NCBITaxon:2017	LOTUS	DOI:10.1039/B615284H

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0001048	Streptoalloteichus hindustanus NCBITaxon:2017	CLUSTER_DEMONSTRATED	genbank:EF032505.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 1

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Assay	Result	Target enzyme	Source detail
NCI In Vivo Anticancer Drug Screen. Data for tumor model B16 Melanoma (subcutaneous) in B6D2F1 (BDF1) mice	ACTIVE	Not recorded	pubchem.aid:194 assay NCI In Vivo Anticancer Drug Screen. Data for tumor model B16 Melanoma (subcutaneous) in B6D2F1 (BDF1) mice evidence reference pubchem.aid:194 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 194, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC

Explore across X-Mech

AntibioticMech (tallysomycin A) ↗ MediaIngredientMech (naturalproductmech:mibig-31266dfbb0) ↗ TaxonMech: Streptoalloteichus hindustanus (NCBITaxon:2017) ↗ PathwayMech (mibig:BGC0001048) ↗

Provenance

Source concept	Source	Version
BGC0001048	MIBIG	5

This page is generated from data/natural_products/amino_acids_and_peptides/tallysomycin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.