thioholgamide A
naturalproductmech:mibig-f10910709b MINTED SEEDED
Structure
| Standard InChIKey | FRMXVRMEEBFTBC-UHFFFAOYSA-O |
|---|---|
| SMILES | CC1C(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC=CS1)C(C2=C[N+](=CN2C)C)O)CC3=CC=CC=C3)C)C(C)C)NC(=O)C(C)NC(=S)C(C)NC(=S)C(C)NC(=O)C(C)NC(=S)C(CCSC)NC(=S)C(C(C)C)NC(=O)C(=O)C |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | npatlas:NPA019832 |
Filing pathway
Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is ribosomal, from MIBiG.
Producer organisms 2
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces sp. NRRL S-87 NCBITaxon:1463920 |
BGC_CHARACTERIZED | mibig:BGC0002669 | PMID:35230829 |
| Streptomyces malaysiense NCBITaxon:1428626 |
SOURCE_ASSERTION | mibig:BGC0001802 | PMID:28981254 |
Occurrences 4
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces malaysiensis NCBITaxon:92644 |
LOTUS | DOI:10.1021/ACS.JNATPROD.7B00607 |
| Streptomyces malaysiensis NCBITaxon:92644 |
LOTUS | DOI:10.1021/ACSCHEMBIO.7B00676 |
| Streptomyces malaysiense NCBITaxon:1428626 |
LOTUS | DOI:10.1021/ACS.JNATPROD.7B00607 |
| Streptomyces malaysiense NCBITaxon:1428626 |
LOTUS | DOI:10.1021/ACSCHEMBIO.7B00676 |
Biosynthetic gene clusters 2
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0002669 | Streptomyces sp. NRRL S-87 NCBITaxon:1463920 |
CLUSTER_DEMONSTRATED | genbank:NZ_JOGB01000003.1 |
| mibig:BGC0001802 | Streptomyces malaysiense NCBITaxon:1428626 |
CLUSTER_UNSTATED | genbank:MF593843.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0001802, BGC0002669. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0002669 | MIBIG | 2 |
| BGC0001802 | MIBIG | 5 |
This page is generated from data/natural_products/amino_acids_and_peptides/thioholgamide-a.yaml, which is generated from the committed inventories. Neither is edited by hand.