thiostreptamide S4
naturalproductmech:mibig-713fc46c0d MINTED SEEDED
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
Structure
| Standard InChIKey | AKETULXCBSMUTF-MYXRQXSUSA-O |
|---|---|
| SMILES | CCC(C)[C@H](NC(=S)[C@H](C)NC(=O)[C@H](C)NC(=S)[C@H](CCSC)NC(=S)[C@@H](NC(=O)C(C)=O)C(C)C)C(=S)N[C@@H](C)C(=O)N[C@@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC2=CC=C(OC)C=C2)C(=O)N[C@@H](C(O)C2=C[N+](C)=CN2C)C(=O)NC=CS[C@@H]1C |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | npatlas:NPA032839 |
Filing pathway
Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is ribosomal, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces sp. NRRL S-4 NCBITaxon:1519471 |
SOURCE_ASSERTION | mibig:BGC0002560 | PMID:34123341 |
Occurrences 1
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.1021/ACSCHEMBIO.7B00677 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0002560 | Streptomyces sp. NRRL S-4 NCBITaxon:1519471 |
CLUSTER_DEMONSTRATED | genbank:LGKJ01000112.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
Explore across X-Mech
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0002560 | MIBIG | 3 |
This page is generated from data/natural_products/amino_acids_and_peptides/thiostreptamide-s4.yaml, which is generated from the committed inventories. Neither is edited by hand.