tyrocidine A

CHEBI:29701 EXACT SEEDED antibacterial

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

A homodetic cyclic decapeptide consisting of D-Phe, L-Pro, L-Phe, D-Phe, L-Asn, L-Gln, L-Tyr, L-Val, L-Orn, and L-Leu residues coupled in sequence and cyclised head-to-tail.

Structure

Standard InChIKey	GSXRBRIWJGAPDU-BBVRJQLQSA-N
SMILES	CC(C)C[C@H]1C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCN)C(C)C)CC3=CC=C(C=C3)O)CCC(=O)N)CC(=O)N)CC4=CC=CC=C4)CC5=CC=CC=C5)CC6=CC=CC=C6
Stereochemistry	fully defined
Cross-references	pubchem:16129635

Filing pathway

Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Brevibacillus brevis NBRC 100599 NCBITaxon:358681	SOURCE_ASSERTION	mibig:BGC0000452	PMID:29594558

Occurrences 4

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Brevibacillus brevis NCBITaxon:1393	LOTUS	DOI:10.1007/S11274-018-2437-4
Brevibacillus brevis NCBITaxon:1393	LOTUS	DOI:10.1021/JA01632A015
Brevibacillus brevis NCBITaxon:1393	CHEBI	PMID:4320358
Phalces brevis NCBITaxon:2815668	LOTUS	DOI:10.1021/JA01632A015

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0000452	Brevibacillus brevis NBRC 100599 NCBITaxon:358681	CLUSTER_UNSTATED	genbank:AP008955.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 1

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Assay	Result	Target enzyme	Source detail
USP28 deubiquitinase inhibition: Primary qHTS	ACTIVE	UniProtKB:Q96RU2	pubchem.aid:1645857 assay USP28 deubiquitinase inhibition: Primary qHTS evidence reference pubchem.aid:1645857 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1645857, deposited by 24642; assay type Other. call ACTIVE target enzyme UniProtKB:Q96RU2

Elsewhere in the fleet

AntibioticMech — CHEBI:29701 (same structure, same inchikey)

Explore across X-Mech

AntibioticMech (tyrocidine A) ↗ MediaIngredientMech (CHEBI:29701) ↗ TaxonMech: Brevibacillus brevis NBRC 100599 (NCBITaxon:358681) ↗ PathwayMech (mibig:BGC0000452) ↗

Provenance

Source concept	Source	Version
BGC0000452	MIBIG	5
CHEBI:29701	CHEBI	3-star

This page is generated from data/natural_products/amino_acids_and_peptides/tyrocidine-a.yaml, which is generated from the committed inventories. Neither is edited by hand.