vibrioferrin

CHEBI:84585 EXACT SEEDED

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

A tricarboxylic acid that is citric acid in which the pro-R carboxy group has been esterified with the primary hydroxy group of 2-hydroxy-1-{(2S)-1-[(2-hydroxyethyl)amino]-1-oxopropan-2-yl}-5-oxoproline. It is a siderophore isolated from bacteria closely associated or symbiotic with toxic, bloom-forming dinoflagellates.

Structure

Standard InChIKey	IGQXNKDXMPSELX-BIAKFKOBSA-N
SMILES	O=C1CCC(O)(C(O)=O)N1[C@@H](C)C(NCCOC(C[C@](C(O)=O)(O)CC(O)=O)=O)=O
Stereochemistry	undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-references	npatlas:NPA024673

Filing pathway

Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.

Producer organisms 2

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Vibrio parahaemolyticus Strain: WP1 NCBITaxon:670	SOURCE_ASSERTION	mibig:BGC0000946	PMID:14617658, https://www.ncbi.nlm.nih.gov/nuccore/AB082123.1 reference PMID:14617658 evidence type DATABASE_ASSERTION notes MIBiG BGC0000946 entry version 5; citation taken from the entry level reference https://www.ncbi.nlm.nih.gov/nuccore/AB082123.1 evidence type CURATOR_INFERENCE notes Strain context: WP1. AB082123.1 names strain WP1. This is the deposited locus strain, not AQ 3354 from the separate ChEBI occurrence. No taxon or evidence grade changes. See issue #933. Taxon identity and evidence grade are unchanged; this is not a species-wide experiment. MIBiG source row BGC0000946:1; SHA256 2a6d88d4055ff04c4496c977d1bc1af425c5f12c860c7c85a591c681734cfe7c. Curator: codex; date: 2026-10-13.
Azotobacter vinelandii CA NCBITaxon:1283330	SOURCE_ASSERTION	mibig:BGC0002527	PMID:26452553, https://mibig.secondarymetabolites.org/repository/BGC0002527.2/annotations.json

Occurrences 5

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Azotobacter vinelandii NCBITaxon:354	LOTUS	DOI:10.1128/AEM.03160-15
Vibrio alginolyticus NCBITaxon:663	CHEBI	PMID:22146715
Vibrio parahaemolyticus NCBITaxon:670	CHEBI	DOI: 10.1111/j.1574-6968.1992.tb05311.x
Vibrio parahaemolyticus NCBITaxon:670	LOTUS	DOI:10.1093/OXFORDJOURNALS.JBCHEM.A124432
Vibrio parahaemolyticus NCBITaxon:670	LOTUS	DOI:10.1128/JB.185.23.6938-6949.2003

Biosynthetic gene clusters 2

Accession	Host	Locus evidence	Genome
mibig:BGC0000946	Vibrio parahaemolyticus NCBITaxon:670	CLUSTER_UNSTATED	genbank:AB082123.1
mibig:BGC0002527	Azotobacter vinelandii CA NCBITaxon:1283330	CLUSTER_UNSTATED	genbank:CP005094.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Explore across X-Mech

AntibioticMech (vibrioferrin) ↗ MediaIngredientMech (CHEBI:84585) ↗ TaxonMech: Vibrio parahaemolyticus (NCBITaxon:670) ↗ TaxonMech: Azotobacter vinelandii CA (NCBITaxon:1283330) ↗ PathwayMech (mibig:BGC0000946) ↗ PathwayMech (mibig:BGC0002527) ↗

Open questions 2

shared-structure — This structure is reported by more than one MIBiG entry: BGC0000946, BGC0002527. Confirm they describe the same compound rather than an upstream cross-reference error.

curator-vibrioferrin-indirect-origin — Which primary experiment supports the ChEBI Vibrio alginolyticus occurrence?

Provenance

Source concept	Source	Version
BGC0000946	MIBIG	5
BGC0002527	MIBIG	2
CHEBI:84585	CHEBI	3-star

This page is generated from data/natural_products/amino_acids_and_peptides/vibrioferrin.yaml, which is generated from the committed inventories. Neither is edited by hand.