capsular polysaccharide

naturalproductmech:mibig-6a3f1200b4 MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	ODLPTSAMUCYJMF-UHFFFAOYSA-N
SMILES	C(C1C(C(C(C(O1)OC2C(C(OC(C2OC3C(C(C(C(O3)C(=O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O)OC5C(OC(C(C5O)O)OCC6C(C(C(C(O6)O)O)O)O)CO)CO)O)O)O)O)O
Stereochemistry	undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-references	pubchem:3083199

Filing pathway

Carbohydrates — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is saccharide, from MIBiG.

Producer organisms 5

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Klebsiella pneumoniae subsp. ozaenae Strain: Kauffmann E5051 NCBITaxon:574	SOURCE_ASSERTION	mibig:BGC0000728	PMID:17599305, https://www.ncbi.nlm.nih.gov/nuccore/AB289645.1 reference PMID:17599305 evidence type DATABASE_ASSERTION notes MIBiG BGC0000728 entry version 5; citation taken from the entry level reference https://www.ncbi.nlm.nih.gov/nuccore/AB289645.1 evidence type CURATOR_INFERENCE notes Strain context: Kauffmann E5051. GenBank AB289645.1 source feature identifies strain Kauffmann E5051 and serotype K5. This qualifies the deposited locus, not exact capsule-product identity, which remains open in issue #935. No taxon, structure or evidence-grade change. See issue #938. Taxon identity and evidence grade are unchanged; this is not a species-wide experiment. MIBiG source row BGC0000728:1; SHA256 33c6a8312ae6f8cb562fdb2d97488c06dfebdda1b4c558b9f81804419a2ebf6c. Curator: codex; date: 2026-10-13.
Klebsiella pneumoniae Strain: NTUH-K9534 NCBITaxon:573	SOURCE_ASSERTION	mibig:BGC0000729	PMID:17599305, https://www.ncbi.nlm.nih.gov/nuccore/AB289646.1 reference PMID:17599305 evidence type DATABASE_ASSERTION notes MIBiG BGC0000729 entry version 3; citation taken from the entry level reference https://www.ncbi.nlm.nih.gov/nuccore/AB289646.1 evidence type CURATOR_INFERENCE notes Strain context: NTUH-K9534. GenBank AB289646.1 source feature identifies strain NTUH-K9534 and serotype K5. This qualifies the deposited locus, not exact capsule-product identity, which remains open in issue #935. No taxon, structure or evidence-grade change. See issue #938. Taxon identity and evidence grade are unchanged; this is not a species-wide experiment. MIBiG source row BGC0000729:1; SHA256 90256f1a1203b425fb4f46d119dc9b8ef1a970fc951e3897afdfb7b9853913ad. Curator: codex; date: 2026-10-13.
Klebsiella pneumoniae Strain: 889/50 NCBITaxon:573	SOURCE_ASSERTION	mibig:BGC0000730	PMID:17599305, https://www.ncbi.nlm.nih.gov/nuccore/AB289647.1 reference PMID:17599305 evidence type DATABASE_ASSERTION notes MIBiG BGC0000730 entry version 3; citation taken from the entry level reference https://www.ncbi.nlm.nih.gov/nuccore/AB289647.1 evidence type CURATOR_INFERENCE notes Strain context: 889/50. GenBank AB289647.1 source feature identifies strain 889/50 and serotype K20. This qualifies the deposited locus, not exact capsule-product identity, which remains open in issue #935. No taxon, structure or evidence-grade change. See issue #938. Taxon identity and evidence grade are unchanged; this is not a species-wide experiment. MIBiG source row BGC0000730:1; SHA256 d274e2ce22c09d99af3d1de8a40973c06ceb85b1ee495c0b20be2c66616c208b. Curator: codex; date: 2026-10-13.
Klebsiella pneumoniae Strain: NTUH-KP13 NCBITaxon:573	SOURCE_ASSERTION	mibig:BGC0000731	PMID:17599305, https://www.ncbi.nlm.nih.gov/nuccore/AB289648.1 reference PMID:17599305 evidence type DATABASE_ASSERTION notes MIBiG BGC0000731 entry version 3; citation taken from the entry level reference https://www.ncbi.nlm.nih.gov/nuccore/AB289648.1 evidence type CURATOR_INFERENCE notes Strain context: NTUH-KP13. GenBank AB289648.1 source feature identifies strain NTUH-KP13 and serotype K20. This qualifies the deposited locus, not exact capsule-product identity, which remains open in issue #935. No taxon, structure or evidence-grade change. See issue #938. Taxon identity and evidence grade are unchanged; this is not a species-wide experiment. MIBiG source row BGC0000731:1; SHA256 9a7eb842cce2c1dcd1a8d4eb95cbe77725c0ccaeab4f583f653a33ba54f20b7a. Curator: codex; date: 2026-10-13.
Klebsiella pneumoniae Strain: NTUH-KP35 NCBITaxon:573	SOURCE_ASSERTION	mibig:BGC0000733	PMID:17599305, https://www.ncbi.nlm.nih.gov/nuccore/AB289650.1 reference PMID:17599305 evidence type DATABASE_ASSERTION notes MIBiG BGC0000733 entry version 3; citation taken from the entry level reference https://www.ncbi.nlm.nih.gov/nuccore/AB289650.1 evidence type CURATOR_INFERENCE notes Strain context: NTUH-KP35. GenBank AB289650.1 source feature identifies strain NTUH-KP35 and serotype K54. This qualifies the deposited locus, not exact capsule-product identity, which remains open in issue #935. No taxon, structure or evidence-grade change. See issue #938. Taxon identity and evidence grade are unchanged; this is not a species-wide experiment. MIBiG source row BGC0000733:1; SHA256 0f9121200f320fe1b3ab1b29c93b45f88b2444a44925b72d6be2b739bd599d71. Curator: codex; date: 2026-10-13.

Occurrences 1

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Klebsiella pneumoniae NCBITaxon:573	LOTUS	DOI:10.1086/519262

Biosynthetic gene clusters 5

Accession	Host	Locus evidence	Genome
mibig:BGC0000728	Klebsiella pneumoniae subsp. ozaenae NCBITaxon:574	CLUSTER_UNSTATED	genbank:AB289645.1
mibig:BGC0000729	Klebsiella pneumoniae NCBITaxon:573	CLUSTER_UNSTATED	genbank:AB289646.1
mibig:BGC0000730	Klebsiella pneumoniae NCBITaxon:573	CLUSTER_UNSTATED	genbank:AB289647.1
mibig:BGC0000731	Klebsiella pneumoniae NCBITaxon:573	CLUSTER_UNSTATED	genbank:AB289648.1
mibig:BGC0000733	Klebsiella pneumoniae NCBITaxon:573	CLUSTER_UNSTATED	genbank:AB289650.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Explore across X-Mech

AntibioticMech (capsular polysaccharide) ↗ MediaIngredientMech (naturalproductmech:mibig-6a3f1200b4) ↗ TaxonMech: Klebsiella pneumoniae subsp. ozaenae (NCBITaxon:574) ↗ TaxonMech: Klebsiella pneumoniae (NCBITaxon:573) ↗ TaxonMech: Klebsiella pneumoniae (NCBITaxon:573) ↗ TaxonMech: Klebsiella pneumoniae (NCBITaxon:573) ↗ PathwayMech (mibig:BGC0000728) ↗ PathwayMech (mibig:BGC0000729) ↗ PathwayMech (mibig:BGC0000730) ↗

Open questions 2

shared-structure — This structure is reported by more than one MIBiG entry: BGC0000728, BGC0000729, BGC0000730, BGC0000731, BGC0000733. Confirm they describe the same compound rather than an upstream cross-reference error.

curator-capsule-exact-product-assignment — Which exact chemical product does each deposited capsule locus support?

Provenance

Source concept	Source	Version
BGC0000728	MIBIG	5
BGC0000729	MIBIG	3
BGC0000730	MIBIG	3
BGC0000731	MIBIG	3
BGC0000733	MIBIG	3

This page is generated from data/natural_products/carbohydrates/capsular-polysaccharide-2.yaml, which is generated from the committed inventories. Neither is edited by hand.