miharamycin B
naturalproductmech:mibig-da8f9208c7 MINTED SEEDED
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
Structure
| Standard InChIKey | JOTXNJQBWBCEHD-UHFFFAOYSA-N |
|---|---|
| SMILES | C1C(C2(C(C(OC(C2O1)N3C=NC4=CN=C(N=C43)N)C(C(=O)O)NC(=O)C(CCCN=C(N)N)N)O)O)O |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | pubchem:202590, npatlas:NPA032770 |
Filing pathway
Carbohydrates — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, nrps, saccharide, from MIBiG.
Producer organisms 2
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces miharaensis NCBITaxon:285483 |
SOURCE_ASSERTION | mibig:BGC0001956 | DOI:10.1021/jacs.9b03021 |
| Streptomyces miharaensis NCBITaxon:285483 |
SOURCE_ASSERTION | mibig:BGC0002479 | PMID:32167762 |
Occurrences 0
None cited.
Biosynthetic gene clusters 2
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001956 | Streptomyces miharaensis NCBITaxon:285483 |
CLUSTER_UNSTATED | genbank:MH534948.1 |
| mibig:BGC0002479 | Streptomyces miharaensis NCBITaxon:285483 |
CLUSTER_DEMONSTRATED | genbank:MN850873.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
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Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0001956, BGC0002479. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001956 | MIBIG | 3 |
| BGC0002479 | MIBIG | 3 |
This page is generated from data/natural_products/carbohydrates/miharamycin-b.yaml, which is generated from the committed inventories. Neither is edited by hand.