neomycin C
CHEBI:53634 EXACT SEEDED
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine C.
Structure
| Standard InChIKey | PGBHMTALBVVCIT-VZXHOKRSSA-N |
|---|---|
| SMILES | NC[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA09494, pubchem:8378 |
Filing pathway
Carbohydrates — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is saccharide, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces fradiae ATCC 10745 = DSM 40063 NCBITaxon:1319510 |
SOURCE_ASSERTION | mibig:BGC0000709 | PMID:19362651 |
Occurrences 3
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces fradiae NCBITaxon:1906 |
LOTUS | DOI:10.1016/S0021-9673(00)94512-6 |
| Streptomyces fradiae NCBITaxon:1906 |
LOTUS | DOI:10.1039/B808734B |
| Streptomyces fradiae NCBITaxon:1906 |
LOTUS | DOI:10.7164/ANTIBIOTICS.45.984 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000709 | Streptomyces fradiae ATCC 10745 = DSM 40063 NCBITaxon:1319510 |
CLUSTER_UNSTATED | genbank:AJ629247.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
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Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000709 | MIBIG | 5 |
| CHEBI:53634 | CHEBI | 3-star |
This page is generated from data/natural_products/carbohydrates/neomycin-c.yaml, which is generated from the committed inventories. Neither is edited by hand.