paromomycin

naturalproductmech:mibig-fb83d937b9 MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	UOZODPSAJZTQNH-VZXHOKRSSA-N
SMILES	NC[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O
Stereochemistry	fully defined
Cross-references	npatlas:NPA0635, pubchem:165580

Filing pathway

Carbohydrates — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is saccharide, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptomyces rimosus subsp. paromomycinus NCBITaxon:92743	SOURCE_ASSERTION	mibig:BGC0000712	PMID:19362651

Occurrences 1

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Streptomyces fradiae NCBITaxon:1906	LOTUS	DOI:10.1039/B808734B

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0000712	Streptomyces rimosus subsp. paromomycinus NCBITaxon:92743	CLUSTER_UNSTATED	genbank:AJ628955.2

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 1

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Assay	Result	Target enzyme	Source detail
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database	ACTIVE	Not recorded	pubchem.aid:1195 assay DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database evidence reference pubchem.aid:1195 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1195, deposited by EPA DSSTox; assay type Other. call ACTIVE

Explore across X-Mech

AntibioticMech (paromomycin) ↗ MediaIngredientMech (naturalproductmech:mibig-fb83d937b9) ↗ TaxonMech: Streptomyces rimosus subsp. paromomycinus (NCBITaxon:92743) ↗ PathwayMech (mibig:BGC0000712) ↗

Provenance

Source concept	Source	Version
BGC0000712	MIBIG	5

This page is generated from data/natural_products/carbohydrates/paromomycin.yaml, which is generated from the committed inventories. Neither is edited by hand.