sangivamycin
CHEBI:85997 EXACT SEEDED enzyme inhibitor
A nucleoside analogue that is adenosine in which the nitrogen at position 7 is replaced by a carbamoyl-substituted carbon. It is a potent inhibitor of protein kinase C.
Structure
| Standard InChIKey | OBZJZDHRXBKKTJ-JTFADIMSSA-N |
|---|---|
| SMILES | NC(=O)C1=CN([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C2=C1C(N)=NC=N2 |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA05297, pubchem:14978 |
Filing pathway
Carbohydrates — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces rimosus NCBITaxon:1927 |
SOURCE_ASSERTION | mibig:BGC0000879 | PMID:18721750 |
Occurrences 2
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.1021/JM00311A005 |
| Streptomyces sparsogenes NCBITaxon:67365 |
LOTUS | DOI:10.1016/S0021-9673(01)83861-9 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000879 | Streptomyces rimosus NCBITaxon:1927 |
CLUSTER_UNSTATED | genbank:EU573979.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Causal graph — bioactivity 2 nodes, 1 edges
Sangivamycin binds human G protein-coupled receptor kinase 6 in the PDB 3NYN co-crystal structure.
| Subject | Predicate | Object | Evidence |
|---|---|---|---|
| sangivamycin | binds | human G protein-coupled receptor kinase 6 | DOI:10.1038/emboj.2010.206 |
Every edge carries its own citation; an uncited edge is refused by the corpus tests.
Bioactivities 1
| Assay | Result | Reference |
|---|---|---|
| Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | KD 1 uM | PMID:20729810 |
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000879 | MIBIG | 5 |
| CHEBI:85997 | CHEBI | 3-star |
This page is generated from data/natural_products/carbohydrates/sangivamycin.yaml, which is generated from the committed inventories. Neither is edited by hand.