sibiromycin
CHEBI:90941 EXACT SEEDED antimicrobial unspecifiedtoxin
An aminoglycoside antibiotic produced by Streptosporangium sibiricum that also exhibits antitumour properties.
Structure
| Standard InChIKey | RAGFPHFDFVNLCG-INYQBOQCSA-N |
|---|---|
| SMILES | CN[C@H]1[C@H](C)O[C@@H](OC2=CC3=C(N[C@H](O)[C@@H]4CC(\C=C\C)=CN4C3=O)C(O)=C2C)[C@H](O)[C@]1(C)O |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA01741, pubchem:6437361 |
Filing pathway
Carbohydrates — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptosporangium sibiricum NCBITaxon:457432 |
SOURCE_ASSERTION | mibig:BGC0000428 | PMID:19270142 |
Occurrences 1
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptosporangium sibiricum NCBITaxon:457432 |
CHEBI | PMID:25960001 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000428 | Streptosporangium sibiricum NCBITaxon:457432 |
CLUSTER_UNSTATED | genbank:FJ768674.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 1
| Assay | Result | Reference |
|---|---|---|
| GENE-TOX mutagenicity studies | ACTIVE | pubchem.aid:1259408 |
Elsewhere in the fleet
- AntibioticMech — CHEBI:90941 (same structure, same inchikey)
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000428 | MIBIG | 5 |
| CHEBI:90941 | CHEBI | 3-star |
This page is generated from data/natural_products/carbohydrates/sibiromycin.yaml, which is generated from the committed inventories. Neither is edited by hand.