sibiromycin

CHEBI:90941 EXACT SEEDED antimicrobial unspecifiedtoxin

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

An aminoglycoside antibiotic produced by Streptosporangium sibiricum that also exhibits antitumour properties.

Structure

Standard InChIKey	RAGFPHFDFVNLCG-INYQBOQCSA-N
SMILES	CN[C@H]1[C@H](C)O[C@@H](OC2=CC3=C(N[C@H](O)[C@@H]4CC(\C=C\C)=CN4C3=O)C(O)=C2C)[C@H](O)[C@]1(C)O
Stereochemistry	fully defined
Cross-references	npatlas:NPA01741, pubchem:6437361

Filing pathway

Carbohydrates — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptosporangium sibiricum NCBITaxon:457432	SOURCE_ASSERTION	mibig:BGC0000428	PMID:19270142

Occurrences 1

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Streptosporangium sibiricum NCBITaxon:457432	CHEBI	PMID:25960001

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0000428	Streptosporangium sibiricum NCBITaxon:457432	CLUSTER_UNSTATED	genbank:FJ768674.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 1

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Assay	Result	Target enzyme	Source detail
GENE-TOX mutagenicity studies	ACTIVE	Not recorded	pubchem.aid:1259408 assay GENE-TOX mutagenicity studies evidence reference pubchem.aid:1259408 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1259408, deposited by 22071; assay type Other. call ACTIVE activity class TOXIN

Elsewhere in the fleet

AntibioticMech — CHEBI:90941 (same structure, same inchikey)

Explore across X-Mech

AntibioticMech (sibiromycin) ↗ MediaIngredientMech (CHEBI:90941) ↗ TaxonMech: Streptosporangium sibiricum (NCBITaxon:457432) ↗ PathwayMech (mibig:BGC0000428) ↗

Provenance

Source concept	Source	Version
BGC0000428	MIBIG	5
CHEBI:90941	CHEBI	3-star

This page is generated from data/natural_products/carbohydrates/sibiromycin.yaml, which is generated from the committed inventories. Neither is edited by hand.