tunicamycin B1

CHEBI:64248 EXACT SEEDED antimicrobial unspecified

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by a pentadec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety.

Structure

Standard InChIKey	QYVMTFXNKNWWFX-YGTZKZKGSA-N
SMILES	CCCCCCCCCCCC/C=C/C(=O)N[C@@H]1[C@H]([C@H]([C@H](O[C@H]1O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)NC(=O)C)C[C@H]([C@@H]3[C@H]([C@H]([C@@H](O3)N4C=CC(=O)NC4=O)O)O)O)O)O
Stereochemistry	fully defined
Cross-references	pubchem:56927834

Filing pathway

Carbohydrates — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptomyces chartreusis NRRL 3882 NCBITaxon:1079985	BGC_CHARACTERIZED	mibig:BGC0000880	PMID:22717438

Occurrences 0

None cited.

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0000880	Streptomyces chartreusis NRRL 3882 NCBITaxon:1079985	CLUSTER_DEMONSTRATED	genbank:HQ172897.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Elsewhere in the fleet

AntibioticMech — CHEBI:64248 (same structure, same inchikey)

Explore across X-Mech

AntibioticMech (tunicamycin B1) ↗ MediaIngredientMech (CHEBI:64248) ↗ TaxonMech: Streptomyces chartreusis NRRL 3882 (NCBITaxon:1079985) ↗ PathwayMech (mibig:BGC0000880) ↗

Provenance

Source concept	Source	Version
BGC0000880	MIBIG	4
CHEBI:64248	CHEBI	3-star

This page is generated from data/natural_products/carbohydrates/tunicamycin-b1.yaml, which is generated from the committed inventories. Neither is edited by hand.