validamycin A
naturalproductmech:mibig-bba7e7bd7d MINTED SEEDED
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
Structure
| Standard InChIKey | JARYYMUOCXVXNK-KIMQLNGNSA-N |
|---|---|
| SMILES | C1[C@@H]([C@H]([C@@H](C([C@H]1N[C@H]2C=C([C@H]([C@@H]([C@H]2O)O)O)CO)O)O)O[C@H]3C(C([C@@H](C(O3)CO)O)O)O)CO |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | npatlas:NPA021209 |
Filing pathway
Carbohydrates — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, saccharide, from MIBiG.
Producer organisms 2
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces hygroscopicus subsp. jinggangensis NCBITaxon:311982 |
BGC_CHARACTERIZED | mibig:BGC0000722 | PMID:16632251 |
| Streptomyces hygroscopicus subsp. limoneus NCBITaxon:264445 |
SOURCE_ASSERTION | mibig:BGC0000723 | PMID:16725283 |
Occurrences 0
None cited.
Biosynthetic gene clusters 2
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000722 | Streptomyces hygroscopicus subsp. jinggangensis NCBITaxon:311982 |
CLUSTER_DEMONSTRATED | genbank:DQ164098.1 |
| mibig:BGC0000723 | Streptomyces hygroscopicus subsp. limoneus NCBITaxon:264445 |
CLUSTER_UNSTATED | genbank:DQ223652.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
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Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0000722, BGC0000723. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000722 | MIBIG | 5 |
| BGC0000723 | MIBIG | 5 |
This page is generated from data/natural_products/carbohydrates/validamycin-a-2.yaml, which is generated from the committed inventories. Neither is edited by hand.