depudecin
CHEBI:64143 EXACT SEEDED
A polyketide obtained from the fungus Alternaria brassicicola and having a highly unusual structure of an 11-carbon chain containing two epoxides and six stereogenic centres. It is an inhibitor of histone deacetylase (HDAC) both in vivo and in vitro and also exhibits anti-angiogenic activity.
Structure
| Standard InChIKey | DLVJMFOLJOOWFS-INMLLLKOSA-N |
|---|---|
| SMILES | C[C@@H](O)[C@@H]1O[C@H]1\C=C\[C@@H]1O[C@H]1[C@H](O)C=C |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA01465, pubchem:6438725 |
Filing pathway
Fatty acids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Alternaria brassicicola NCBITaxon:29001 |
BGC_CHARACTERIZED | mibig:BGC0000046 | PMID:19737099 |
Occurrences 3
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Xylaria NCBITaxon:37991 |
LOTUS | DOI:10.1055/S-2000-8588 |
| Alternaria brassicicola NCBITaxon:29001 |
LOTUS | DOI:10.1094/MPMI-22-10-1258 |
| Alternaria brassicicola NCBITaxon:29001 |
LOTUS | DOI:10.7164/ANTIBIOTICS.45.879 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000046 | Alternaria brassicicola NCBITaxon:29001 |
CLUSTER_DEMONSTRATED | genbank:FJ977165.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000046 | MIBIG | 4 |
| CHEBI:64143 | CHEBI | 3-star |
This page is generated from data/natural_products/fatty_acids/depudecin.yaml, which is generated from the committed inventories. Neither is edited by hand.