FR901464
CHEBI:65915 EXACT SEEDED antimicrobial unspecified
A spiro-epoxide with potent anticancer activity that lowers the mRNA levels of oncogenes and tumour supressor genes. It is isolated from Pseudomonas sp. no.2663.
Structure
| Standard InChIKey | PJKVJJDQXZARCA-QHYZBLTGSA-N |
|---|---|
| SMILES | C[C@H]1C[C@H]([C@H](O[C@H]1C/C=C(\C)/C=C/[C@@H]2[C@H]([C@@]3(C[C@@](O2)(C)O)CO3)O)C)NC(=O)/C=C\[C@H](C)OC(=O)C |
| Stereochemistry | fully defined |
| Cross-references | pubchem:10553647 |
Filing pathway
Fatty acids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Burkholderia sp. FERM BP-3421 NCBITaxon:1494466 |
SOURCE_ASSERTION | mibig:BGC0001113 | PMID:25097259 |
Occurrences 2
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Burkholderia thailandensis NCBITaxon:57975 |
LOTUS | DOI:10.1021/NP300913H |
| Pseudomonas sp. 2663 NCBITaxon:764483 |
CHEBI | PMID:9031664 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001113 | Burkholderia sp. FERM BP-3421 NCBITaxon:1494466 |
CLUSTER_UNSTATED | genbank:KJ461964.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Elsewhere in the fleet
- AntibioticMech — CHEBI:65915 (same structure, same inchikey)
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001113 | MIBIG | 5 |
| CHEBI:65915 | CHEBI | 3-star |
This page is generated from data/natural_products/fatty_acids/fr901464.yaml, which is generated from the committed inventories. Neither is edited by hand.