triacsin C

CHEBI:144441 EXACT SEEDED antiparasitic

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

A nitroso compound that is N-undecylnitrous hydrazide carrying double bonds at positions 1,2,4, and 7. It is a long-chain fatty acyl CoA synthetase inhibitor and interferes with lipid metabolism by inhibiting the de novo synthesis of glycerolipids and cholesterol esters.

Structure

Standard InChIKey	NKTGCVUIESDXPU-YLEPRARLSA-N
SMILES	CCC/C=C/C/C=C/C=C/C=N/NN=O
Stereochemistry	fully defined
Cross-references	pubchem:9576787

Filing pathway

Fatty acids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Kitasatospora aureofaciens NCBITaxon:1894	SOURCE_ASSERTION	mibig:BGC0001983	PMID:30589194

Occurrences 1

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Streptomyces aureofaciens NCBITaxon:1894	CHEBI	PMID:6804425

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0001983	Kitasatospora aureofaciens NCBITaxon:1894	CLUSTER_UNSTATED	genbank:MK932017.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 7

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Assay	Result	Target enzyme	Source detail
Confirmation Concentration-Response Assay for lipid storage modulators: for probe SAR	OTHER 0.7911 uM; ACTIVE	Not recorded	pubchem.aid:488913 assay Confirmation Concentration-Response Assay for lipid storage modulators: for probe SAR evidence reference pubchem.aid:488913 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 488913, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. call ACTIVE measurement type OTHER value 0.7911 units uM
Confirmation Concentration-Response Assay for lipid storage modulators: for probe SAR round 2	OTHER 2.807 uM; ACTIVE	Not recorded	pubchem.aid:504432 assay Confirmation Concentration-Response Assay for lipid storage modulators: for probe SAR round 2 evidence reference pubchem.aid:504432 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 504432, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. call ACTIVE measurement type OTHER value 2.807 units uM
Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2	OTHER 50.1187 uM; NOT_DETERMINED	Not recorded	pubchem.aid:1671190 assay Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2 evidence reference pubchem.aid:1671190 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1671190, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 50.1187 units uM
Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2	OTHER 50.1187 uM; NOT_DETERMINED	UniProtKB:P18054	pubchem.aid:1671190 assay Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2 evidence reference pubchem.aid:1671190 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1671190, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 50.1187 units uM target enzyme UniProtKB:P18054
Secondary Assay for lipid storage modulators: AML12 cell LDSA assay for probe SAR	OTHER 0.4992 uM; ACTIVE	Not recorded	pubchem.aid:504434 assay Secondary Assay for lipid storage modulators: AML12 cell LDSA assay for probe SAR evidence reference pubchem.aid:504434 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 504434, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. call ACTIVE measurement type OTHER value 0.4992 units uM
Secondary Assay for lipid storage modulators: Hela cell LDSA assay for probe SAR	OTHER 0.0112 uM; ACTIVE	Not recorded	pubchem.aid:488900 assay Secondary Assay for lipid storage modulators: Hela cell LDSA assay for probe SAR evidence reference pubchem.aid:488900 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 488900, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. call ACTIVE measurement type OTHER value 0.0112 units uM
Secondary Assay for lipid storage modulators: HepG2 cell LDSA assay for probe SAR	OTHER 0.3965 uM; ACTIVE	Not recorded	pubchem.aid:492960 assay Secondary Assay for lipid storage modulators: HepG2 cell LDSA assay for probe SAR evidence reference pubchem.aid:492960 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 492960, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. call ACTIVE measurement type OTHER value 0.3965 units uM

Elsewhere in the fleet

AntibioticMech — CHEBI:144441 (same structure, same inchikey)

Explore across X-Mech

AntibioticMech (triacsin C) ↗ MediaIngredientMech (CHEBI:144441) ↗ TaxonMech: Kitasatospora aureofaciens (NCBITaxon:1894) ↗ PathwayMech (mibig:BGC0001983) ↗

Provenance

Source concept	Source	Version
BGC0001983	MIBIG	3
CHEBI:144441	CHEBI	3-star

This page is generated from data/natural_products/fatty_acids/triacsin-c.yaml, which is generated from the committed inventories. Neither is edited by hand.