1233A

naturalproductmech:mibig-929bdafcd6 MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	ODCZJZWSXPVLAW-UHFFFAOYSA-N
SMILES	CC(=CC(=O)O)C=C(C)CC(C)CCCCC1OC(=O)C1CO
Stereochemistry	undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-references	pubchem:6440895, npatlas:NPA032750

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Fusarium sp. NCBITaxon:29916	BGC_CHARACTERIZED	mibig:BGC0002525	PMID:32139880

Occurrences 0

None cited.

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0002525	Fusarium sp. NCBITaxon:29916	CLUSTER_DEMONSTRATED	genbank:LC516401.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 2

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Assay	Result	Target enzyme	Source detail
Rat hydroxymethylglutaryl-CoA synthase 1 (Lanosterol biosynthesis pathway)	ACTIVE	Not recorded	PMID:2890166 assay Rat hydroxymethylglutaryl-CoA synthase 1 (Lanosterol biosynthesis pathway) evidence reference PMID:2890166 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1346846, deposited by IUPHAR-DB; assay type Other. Target accession NP_058964 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE
Rat hydroxymethylglutaryl-CoA synthase 1 (Lanosterol biosynthesis pathway)	ACTIVE	Not recorded	PMID:8094614 assay Rat hydroxymethylglutaryl-CoA synthase 1 (Lanosterol biosynthesis pathway) evidence reference PMID:8094614 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1346846, deposited by IUPHAR-DB; assay type Other. Target accession NP_058964 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE

Explore across X-Mech

AntibioticMech (1233A) ↗ MediaIngredientMech (naturalproductmech:mibig-929bdafcd6) ↗ TaxonMech: Fusarium sp. (NCBITaxon:29916) ↗ PathwayMech (mibig:BGC0002525) ↗

Open questions 1

needs-a-name — This record is labelled '1233A', which is a label from the cited paper's own numbering rather than a compound name. Resolve a name from the literature or a structure registry.

Provenance

Source concept	Source	Version
BGC0002525	MIBIG	3

This page is generated from data/natural_products/polyketides/1233a.yaml, which is generated from the committed inventories. Neither is edited by hand.