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4-epi-15-epi-brefeldin A

naturalproductmech:mibig-302fcb080c MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.
What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKeyKQNZDYYTLMIZCT-QQRMDHKLSA-N
SMILES[H][C@@]12C[C@H](O)C[C@@]1([H])[C@@H](O)\C=C\C(=O)O[C@H](C)CCC\C=C\2
Stereochemistryfully defined
Cross-referencesnpatlas:NPA018651

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

TaxonBasisClusterEvidence
Penicillium brefeldianum
NCBITaxon:1131482		 BGC_CHARACTERIZED mibig:BGC0001141 DOI:10.1016/j.phytochem.2022.113243

Occurrences 0

None cited.

Biosynthetic gene clusters 1

AccessionHostLocus evidenceGenome
mibig:BGC0001141 Penicillium brefeldianum
NCBITaxon:1131482 		CLUSTER_DEMONSTRATED genbank:KJ728786.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

PRODUCERS & OCCURRENCE 1 producer (1 causal) 0 cited occurrences BIOSYNTHETIC LOCUS 1 gene cluster 0 curated pathway steps NATURAL PRODUCT 4-epi-15-epi-brefeldin A naturalproductmech:mibig-302fcb080c Polyketides TARGETS & BIOACTIVITY 0 molecular targets 0 bioactivities · 0 graphs

Explore across X-Mech

AntibioticMech (4-epi-15-epi-brefeldin A) ↗ MediaIngredientMech (naturalproductmech:mibig-302fcb080c) ↗ TaxonMech: Penicillium brefeldianum (NCBITaxon:1131482) ↗ PathwayMech (mibig:BGC0001141) ↗

Provenance

Source conceptSourceVersion
BGC0001141MIBIG4

This page is generated from data/natural_products/polyketides/4-epi-15-epi-brefeldin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.