NaturalProductMech

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A-factor

naturalproductmech:mibig-60e3158633 MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.
What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKeyREAWNMHCBIUKLZ-RWANSRKNSA-N
SMILESCC(C)CCCCC(=O)C1[C@@H](COC1=O)CO
Stereochemistry undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-referencespubchem:119102

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

TaxonBasisClusterEvidence
Streptomyces griseus subsp. griseus NBRC 13350
NCBITaxon:455632		 SOURCE_ASSERTION mibig:BGC0000848 PMID:18375553

Occurrences 24

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

TaxonSourceReference
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1099/00221287-129-9-2939
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1128/AEM.71.9.5050-5055.2005
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1128/JB.173.7.2311-2318.1991
Streptomyces coelicolor
NCBITaxon:1902		 LOTUS DOI:10.1099/00221287-129-9-2939
Streptomyces coelicolor
NCBITaxon:1902		 LOTUS DOI:10.1128/AEM.71.9.5050-5055.2005
Streptomyces coelicolor
NCBITaxon:1902		 LOTUS DOI:10.1128/JB.173.7.2311-2318.1991
Streptomyces griseus
NCBITaxon:1911		 LOTUS DOI:10.1007/BF00264220
Streptomyces griseus
NCBITaxon:1911		 LOTUS DOI:10.1007/S12275-011-0330-Z
Streptomyces griseus
NCBITaxon:1911		 LOTUS DOI:10.1039/C2OB06653J
Streptomyces griseus
NCBITaxon:1911		 LOTUS DOI:10.1046/J.1365-2958.1999.01579.X
Streptomyces griseus
NCBITaxon:1911		 LOTUS DOI:10.1046/J.1365-2958.2003.03760.X
Streptomyces griseus
NCBITaxon:1911		 LOTUS DOI:10.1099/00221287-129-9-2939
Streptomyces griseus
NCBITaxon:1911		 LOTUS DOI:10.1099/13500872-145-5-1161
Streptomyces griseus
NCBITaxon:1911		 LOTUS DOI:10.1099/MIC.0.027862-0
Streptomyces griseus
NCBITaxon:1911		 LOTUS DOI:10.1111/J.1365-2958.1994.TB01073.X
Streptomyces griseus
NCBITaxon:1911		 LOTUS DOI:10.1111/J.1365-2958.2009.06814.X
Streptomyces griseus
NCBITaxon:1911		 LOTUS DOI:10.1128/JB.00204-08
Streptomyces griseus
NCBITaxon:1911		 LOTUS DOI:10.1128/JB.171.2.1206-1210.1989
Streptomyces griseus
NCBITaxon:1911		 LOTUS DOI:10.1128/JB.172.6.3003-3008.1990
Streptomyces griseus
NCBITaxon:1911		 LOTUS DOI:10.1128/JB.177.21.6083-6092.1995
Streptomyces griseus
NCBITaxon:1911		 LOTUS DOI:10.1128/JB.177.22.6401-6410.1995
Streptomyces griseus
NCBITaxon:1911		 LOTUS DOI:10.1128/JB.185.4.1273-1283.2003
Streptomyces griseus
NCBITaxon:1911		 LOTUS DOI:10.7164/ANTIBIOTICS.57.218
Streptomyces hygroscopicus
NCBITaxon:1912		 LOTUS DOI:10.1002/BIT.24965

Biosynthetic gene clusters 1

AccessionHostLocus evidenceGenome
mibig:BGC0000848 Streptomyces griseus subsp. griseus NBRC 13350
NCBITaxon:455632 		CLUSTER_UNSTATED genbank:AP009493.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

PRODUCERS & OCCURRENCE 1 producer (0 causal) 24 cited occurrences BIOSYNTHETIC LOCUS 1 gene cluster 0 curated pathway steps NATURAL PRODUCT A-factor naturalproductmech:mibig-60e3158633 Polyketides TARGETS & BIOACTIVITY 0 molecular targets 0 bioactivities · 0 graphs

Explore across X-Mech

AntibioticMech (A-factor) ↗ MediaIngredientMech (naturalproductmech:mibig-60e3158633) ↗ TaxonMech: Streptomyces griseus subsp. griseus NBRC 13350 (NCBITaxon:455632) ↗ PathwayMech (mibig:BGC0000848) ↗

Provenance

Source conceptSourceVersion
BGC0000848MIBIG5

This page is generated from data/natural_products/polyketides/a-factor.yaml, which is generated from the committed inventories. Neither is edited by hand.