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actinorhodin

naturalproductmech:mibig-a2d0f9972a MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.
What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKeyFXTIILIJTTYSLT-WYUUTHIRSA-N
SMILESC[C@@H]1C2=C(C3=C(C(=O)C=C(C3=O)C4=CC(=O)C5=C(C4=O)C(=C6[C@H](O[C@@H](CC6=C5O)CC(=O)O)C)O)C(=C2C[C@H](O1)CC(=O)O)O)O
Stereochemistryfully defined
Cross-referencesCHEBI:2448, pubchem:5280985

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

TaxonBasisClusterEvidence
Streptomyces coelicolor A3(2)
NCBITaxon:100226		 BGC_CHARACTERIZED mibig:BGC0000194 DOI:10.1002/ange.201814172

Occurrences 25

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

TaxonSourceReference
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1002/(SICI)1097-0290(19970620)54:6<577::AID-BIT8>3.0.CO;2-G
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1007/BF00186959
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1007/BF00339742
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1007/BF02931330
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1007/S00203-004-0669-1
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1007/S00203-011-0721-X
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1007/S00203-014-1000-4
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1007/S00253-007-1184-5
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1007/S00253-008-1574-3
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1007/S00253-008-1802-X
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1007/S00253-009-2368-Y
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1007/S00253-009-2412-Y
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1007/S00253-012-4129-6
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1007/S00253-018-8838-3
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1007/S00438-002-0730-1
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1007/S10295-009-0591-2
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1007/S10482-011-9657-Z
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1007/S10529-012-0987-3
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1016/0014-5793(96)00756-9
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1016/0378-1119(96)00310-1
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1016/B978-0-12-404634-4.00014-0
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1016/J.BBAEXP.2005.06.005
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1016/J.FEBSLET.2005.04.019
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1016/J.GENE.2011.01.005
Streptomyces albidoflavus
NCBITaxon:1886		 LOTUS DOI:10.1016/J.JMB.2007.12.061

Biosynthetic gene clusters 1

AccessionHostLocus evidenceGenome
mibig:BGC0000194 Streptomyces coelicolor A3(2)
NCBITaxon:100226 		CLUSTER_DEMONSTRATED genbank:AL645882.2

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

PRODUCERS & OCCURRENCE 1 producer (1 causal) 25 cited occurrences BIOSYNTHETIC LOCUS 1 gene cluster 0 curated pathway steps NATURAL PRODUCT actinorhodin naturalproductmech:mibig-a2d0f9972a Polyketides TARGETS & BIOACTIVITY 0 molecular targets 0 bioactivities · 0 graphs

Explore across X-Mech

AntibioticMech (actinorhodin) ↗ MediaIngredientMech (naturalproductmech:mibig-a2d0f9972a) ↗ TaxonMech: Streptomyces coelicolor A3(2) (NCBITaxon:100226) ↗ PathwayMech (mibig:BGC0000194) ↗

Open questions 1

structure-disagreement — MIBiG cross-references this compound to CHEBI:2448, but ChEBI holds CHEBI:2448 with Standard InChIKey VTIKDEXOEJDMJP-WYUUTHIRSA-N and this record's structure is FXTIILIJTTYSLT-WYUUTHIRSA-N. The skeleton blocks differ, so these are not the same molecule: one of the two databases has the wrong structure for this name. Check which, and report it upstream.

Provenance

Source conceptSourceVersion
BGC0000194MIBIG5

This page is generated from data/natural_products/polyketides/actinorhodin.yaml, which is generated from the committed inventories. Neither is edited by hand.