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aflatoxin B2

CHEBI:48209 EXACT SEEDED toxin

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

An aflatoxin having a hexahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.

Structure

Standard InChIKeyWWSYXEZEXMQWHT-WNWIJWBNSA-N
SMILESCOc1cc2c(c3c1c4c(c(=O)o3)C(=O)CC4)[C@@H]5CCO[C@@H]5O2
Stereochemistryfully defined
Cross-referencesnpatlas:NPA010640, pubchem:2724360

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 3

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

TaxonBasisClusterEvidence
Aspergillus flavus
NCBITaxon:5059		 SOURCE_ASSERTION mibig:BGC0000006 DOI:10.1534/g3.120.401405
Aspergillus flavus
NCBITaxon:5059		 SOURCE_ASSERTION mibig:BGC0000008 DOI:10.1371/journal.pone.0199169
Aspergillus ochraceoroseus
NCBITaxon:138278		 SOURCE_ASSERTION mibig:BGC0000011 DOI:10.1080/15572536.2006.11832818

Occurrences 4

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

TaxonSourceReference
Aspergillus nomiae
NCBITaxon:41061		 LOTUS DOI:10.1016/B978-0-12-179760-7.50023-1
Aspergillus parasiticus
NCBITaxon:5067		 LOTUS DOI:10.1016/B978-0-12-179760-7.50023-1
Glycyrrhiza uralensis
NCBITaxon:74613		 LOTUS DOI:10.1016/J.FOODCONT.2012.11.028
Aspergillus flavus
NCBITaxon:5059		 LOTUS DOI:10.1016/B978-0-12-179760-7.50023-1

Biosynthetic gene clusters 3

AccessionHostLocus evidenceGenome
mibig:BGC0000006 Aspergillus flavus
NCBITaxon:5059 		CLUSTER_UNSTATED genbank:AY510451.1
mibig:BGC0000008 Aspergillus flavus
NCBITaxon:5059 		CLUSTER_UNSTATED genbank:AY510453.1
mibig:BGC0000011 Aspergillus ochraceoroseus
NCBITaxon:138278 		CLUSTER_UNSTATED genbank:AY092402.3

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

PRODUCERS & OCCURRENCE 3 producers (0 causal) 4 cited occurrences BIOSYNTHETIC LOCUS 3 gene clusters 0 curated pathway steps NATURAL PRODUCT aflatoxin B2 CHEBI:48209 Polyketides TARGETS & BIOACTIVITY 0 molecular targets 3 bioactivities · 0 graphs

Bioactivities 3

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

AssayResultTarget enzymeSource detail
CCRIS carcinogenicity studiesACTIVENot recorded
pubchem.aid:1259411
assay
CCRIS carcinogenicity studies
evidence
  • reference
    pubchem.aid:1259411
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1259411, deposited by 22070; assay type Other.
call
ACTIVE
activity class
TOXIN
CCRIS mutagenicity studiesACTIVENot recorded
pubchem.aid:1259407
assay
CCRIS mutagenicity studies
evidence
  • reference
    pubchem.aid:1259407
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1259407, deposited by 22070; assay type Other.
call
ACTIVE
activity class
TOXIN
GENE-TOX mutagenicity studiesACTIVENot recorded
pubchem.aid:1259408
assay
GENE-TOX mutagenicity studies
evidence
  • reference
    pubchem.aid:1259408
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1259408, deposited by 22071; assay type Other.
call
ACTIVE
activity class
TOXIN

Explore across X-Mech

AntibioticMech (aflatoxin B2) ↗ MediaIngredientMech (CHEBI:48209) ↗ TaxonMech: Aspergillus flavus (NCBITaxon:5059) ↗ TaxonMech: Aspergillus flavus (NCBITaxon:5059) ↗ TaxonMech: Aspergillus ochraceoroseus (NCBITaxon:138278) ↗ PathwayMech (mibig:BGC0000006) ↗ PathwayMech (mibig:BGC0000008) ↗ PathwayMech (mibig:BGC0000011) ↗

Open questions 1

shared-structure — This structure is reported by more than one MIBiG entry: BGC0000006, BGC0000008, BGC0000011. Confirm they describe the same compound rather than an upstream cross-reference error.

Provenance

Source conceptSourceVersion
BGC0000006MIBIG3
BGC0000008MIBIG3
BGC0000011MIBIG3
CHEBI:48209CHEBI3-star

This page is generated from data/natural_products/polyketides/aflatoxin-b2.yaml, which is generated from the committed inventories. Neither is edited by hand.