amphotericin B
naturalproductmech:mibig-b80aecf6de MINTED SEEDED antiviralcytotoxic
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
Structure
| Standard InChIKey | APKFDSVGJQXUKY-UPWJBAEMSA-N |
|---|---|
| SMILES | C[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](C[C@H]2[C@@H]([C@H](C[C@](O2)(C[C@H](C[C@H]([C@@H](CC[C@H](C[C@H](CC(=O)O[C@H]([C@@H]([C@@H]1O)C)C)O)O)O)O)O)O)O)C(=O)O)OC3C(C(C(C(O3)C)O)N)O |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | pubchem:5386092 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces nodosus NCBITaxon:40318 |
SOURCE_ASSERTION | mibig:BGC0000016 | PMID:15563836 |
Occurrences 0
None cited.
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000016 | Streptomyces nodosus NCBITaxon:40318 |
CLUSTER_UNSTATED | genbank:AY636001.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
Bioactivities 18
Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.
| Assay | Result | Target enzyme | Source detail |
|---|---|---|---|
| MDR-1 | ACTIVE | Not recorded | pubchem.aid:377
|
| NCI AIDS Antiviral Assay | ACTIVE | Not recorded | pubchem.aid:179
|
| NCI Yeast Anticancer Drug Screen. Data for the CLN2oe strain | ACTIVE | Not recorded | pubchem.aid:163
|
| NCI Yeast Anticancer Drug Screen. Data for the bub3 strain | ACTIVE | Not recorded | pubchem.aid:167
|
| NCI Yeast Anticancer Drug Screen. Data for the cln2 rad14 strain | ACTIVE | Not recorded | pubchem.aid:165
|
| NCI Yeast Anticancer Drug Screen. Data for the mec2-1 strain | ACTIVE | Not recorded | pubchem.aid:157
|
| NCI Yeast Anticancer Drug Screen. Data for the mgt1 strain | ACTIVE | Not recorded | pubchem.aid:153
|
| NCI Yeast Anticancer Drug Screen. Data for the mlh1 rad18 strain | ACTIVE | Not recorded | pubchem.aid:175
|
| NCI Yeast Anticancer Drug Screen. Data for the mlh1 strain | ACTIVE | Not recorded | pubchem.aid:171
|
| NCI Yeast Anticancer Drug Screen. Data for the rad14 strain | ACTIVE | Not recorded | pubchem.aid:159
|
| NCI Yeast Anticancer Drug Screen. Data for the rad18 strain | ACTIVE | Not recorded | pubchem.aid:177
|
| NCI Yeast Anticancer Drug Screen. Data for the rad50 strain | ACTIVE | Not recorded | pubchem.aid:155
|
| NCI Yeast Anticancer Drug Screen. Data for the rad50EPP+ strain | ACTIVE | Not recorded | pubchem.aid:151
|
| NCI Yeast Anticancer Drug Screen. Data for the rad52 strain | ACTIVE | Not recorded | pubchem.aid:147
|
| NCI Yeast Anticancer Drug Screen. Data for the sgs1 mgt1 strain | ACTIVE | Not recorded | pubchem.aid:161
|
| NCI Yeast Anticancer Drug Screen. Data for the sgs1 strain | ACTIVE | Not recorded | pubchem.aid:173
|
| NCI Yeast Anticancer Drug Screen. Data for the wt1 strain | ACTIVE | Not recorded | pubchem.aid:149
|
| NCI Yeast Anticancer Drug Screen. Data for the wt2 strain | ACTIVE | Not recorded | pubchem.aid:169
|
Explore across X-Mech
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000016 | MIBIG | 4 |
This page is generated from data/natural_products/polyketides/amphotericin-b.yaml, which is generated from the committed inventories. Neither is edited by hand.