asukamycin
naturalproductmech:mibig-9ca881fcd0 MINTED SEEDED
Structure
| Standard InChIKey | SSHVAUUEPNULMP-PVYHIPRASA-N |
|---|---|
| SMILES | OC1=C(NC(=O)\C=C\C=C/C=C\[C@]2(O)C=C(NC(=O)\C=C\C=C\C=C\C3CCCCC3)C(=O)C3OC23)C(=O)CC1 |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | npatlas:NPA012374, pubchem:6441014 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces nodosus subsp. asukaensis NCBITaxon:222892 |
BGC_CHARACTERIZED | mibig:BGC0000187 | PMID:25489112 |
Occurrences 0
None cited.
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000187 | Streptomyces nodosus subsp. asukaensis NCBITaxon:222892 |
CLUSTER_DEMONSTRATED | genbank:GQ926890.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 9
| Assay | Result | Reference |
|---|---|---|
| OTUD3 deubiquitinase inhibition: Dose-response Confirmation | ACTIVE | pubchem.aid:1645868 |
| OTUD3 deubiquitinase inhibition: Primary qHTS | ACTIVE | pubchem.aid:1645858 |
| UCHL1 deubiquitinase inhibition: Primary qHTS | ACTIVE | pubchem.aid:1645859 |
| USP10 deubiquitinase inhibition: Dose-response Confirmation | ACTIVE | pubchem.aid:1645863 |
| USP17 deubiquitinase inhibition: Dose-response Confirmation | ACTIVE | pubchem.aid:1645864 |
| USP17 deubiquitinase inhibition: Primary qHTS | ACTIVE | pubchem.aid:1645855 |
| USP28 deubiquitinase inhibition: Dose-response Confirmation | ACTIVE | pubchem.aid:1645866 |
| USP28 deubiquitinase inhibition: Primary qHTS | ACTIVE | pubchem.aid:1645857 |
| USP7 deubiquitinase inhibition: Primary qHTS | ACTIVE | pubchem.aid:1645854 |
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000187 | MIBIG | 5 |
This page is generated from data/natural_products/polyketides/asukamycin.yaml, which is generated from the committed inventories. Neither is edited by hand.