asukamycin

naturalproductmech:mibig-9ca881fcd0 MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	SSHVAUUEPNULMP-PVYHIPRASA-N
SMILES	OC1=C(NC(=O)\C=C\C=C/C=C\[C@]2(O)C=C(NC(=O)\C=C\C=C\C=C\C3CCCCC3)C(=O)C3OC23)C(=O)CC1
Stereochemistry	undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-references	npatlas:NPA012374, pubchem:6441014

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptomyces nodosus subsp. asukaensis NCBITaxon:222892	BGC_CHARACTERIZED	mibig:BGC0000187	PMID:25489112

Occurrences 0

None cited.

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0000187	Streptomyces nodosus subsp. asukaensis NCBITaxon:222892	CLUSTER_DEMONSTRATED	genbank:GQ926890.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 9

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Assay	Result	Target enzyme	Source detail
OTUD3 deubiquitinase inhibition: Dose-response Confirmation	ACTIVE	Not recorded	pubchem.aid:1645868 assay OTUD3 deubiquitinase inhibition: Dose-response Confirmation evidence reference pubchem.aid:1645868 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1645868, deposited by 24642; assay type Confirmatory. Target accession NP_056022 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE
OTUD3 deubiquitinase inhibition: Primary qHTS	ACTIVE	Not recorded	pubchem.aid:1645858 assay OTUD3 deubiquitinase inhibition: Primary qHTS evidence reference pubchem.aid:1645858 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1645858, deposited by 24642; assay type Other. Target accession NP_056022 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE
UCHL1 deubiquitinase inhibition: Primary qHTS	ACTIVE	UniProtKB:P09936	pubchem.aid:1645859 assay UCHL1 deubiquitinase inhibition: Primary qHTS evidence reference pubchem.aid:1645859 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1645859, deposited by 24642; assay type Other. call ACTIVE target enzyme UniProtKB:P09936
USP10 deubiquitinase inhibition: Dose-response Confirmation	ACTIVE	UniProtKB:Q14694	pubchem.aid:1645863 assay USP10 deubiquitinase inhibition: Dose-response Confirmation evidence reference pubchem.aid:1645863 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1645863, deposited by 24642; assay type Confirmatory. call ACTIVE target enzyme UniProtKB:Q14694
USP17 deubiquitinase inhibition: Dose-response Confirmation	ACTIVE	UniProtKB:A8MUK1	pubchem.aid:1645864 assay USP17 deubiquitinase inhibition: Dose-response Confirmation evidence reference pubchem.aid:1645864 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1645864, deposited by 24642; assay type Confirmatory. call ACTIVE target enzyme UniProtKB:A8MUK1
USP17 deubiquitinase inhibition: Primary qHTS	ACTIVE	UniProtKB:A8MUK1	pubchem.aid:1645855 assay USP17 deubiquitinase inhibition: Primary qHTS evidence reference pubchem.aid:1645855 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1645855, deposited by 24642; assay type Other. call ACTIVE target enzyme UniProtKB:A8MUK1
USP28 deubiquitinase inhibition: Dose-response Confirmation	ACTIVE	UniProtKB:Q96RU2	pubchem.aid:1645866 assay USP28 deubiquitinase inhibition: Dose-response Confirmation evidence reference pubchem.aid:1645866 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1645866, deposited by 24642; assay type Confirmatory. call ACTIVE target enzyme UniProtKB:Q96RU2
USP28 deubiquitinase inhibition: Primary qHTS	ACTIVE	UniProtKB:Q96RU2	pubchem.aid:1645857 assay USP28 deubiquitinase inhibition: Primary qHTS evidence reference pubchem.aid:1645857 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1645857, deposited by 24642; assay type Other. call ACTIVE target enzyme UniProtKB:Q96RU2
USP7 deubiquitinase inhibition: Primary qHTS	ACTIVE	Not recorded	pubchem.aid:1645854 assay USP7 deubiquitinase inhibition: Primary qHTS evidence reference pubchem.aid:1645854 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1645854, deposited by 24642; assay type Other. Target accession NP_003461 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE

Explore across X-Mech

AntibioticMech (asukamycin) ↗ MediaIngredientMech (naturalproductmech:mibig-9ca881fcd0) ↗ TaxonMech: Streptomyces nodosus subsp. asukaensis (NCBITaxon:222892) ↗ PathwayMech (mibig:BGC0000187) ↗

Provenance

Source concept	Source	Version
BGC0000187	MIBIG	5

This page is generated from data/natural_products/polyketides/asukamycin.yaml, which is generated from the committed inventories. Neither is edited by hand.