NaturalProductMech

borrelidin

naturalproductmech:mibig-af79f8ac64 MINTED SEEDED

Structure

Standard InChIKeyOJCKRNPLOZHAOU-UGKRXNSESA-N
SMILES[H][C@]1(CCC[C@H]1C(O)=O)[C@]1([H])C\C=C\C=C(C#N)/[C@H](O)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)[C@@H](O)CC(=O)O1
Stereochemistryfully defined
Cross-referencesnpatlas:NPA011087

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 2

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

TaxonBasisClusterEvidence
Streptomyces parvulus
NCBITaxon:146923
BGC_CHARACTERIZED mibig:BGC0000031 PMID:15112998
Streptomyces rochei
NCBITaxon:1928
SOURCE_ASSERTION mibig:BGC0001533 PMID:27451447

Occurrences 9

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

TaxonSourceReference
Streptomyces coelicoflavus
NCBITaxon:285562
LOTUS DOI:10.3389/FMICB.2016.00659
Streptomyces albovinaceus
NCBITaxon:66867
LOTUS DOI:10.1128/AAC.27.2.239
Streptomyces mutabilis
NCBITaxon:67332
LOTUS DOI:10.1515/ZNC-2017-0140
Streptomyces heilongjiangensis
NCBITaxon:945052
LOTUS DOI:10.1099/IJS.0.041483-0
Streptomyces parvulus
NCBITaxon:146923
LOTUS DOI:10.1016/J.CHEMBIOL.2003.12.018
Streptomyces parvulus
NCBITaxon:146923
LOTUS DOI:10.1111/J.1365-2958.2004.04090.X
Streptomyces rochei
NCBITaxon:1928
LOTUS DOI:10.1002/HLCA.19670500303
Streptomyces rochei
NCBITaxon:1928
LOTUS DOI:10.1007/S00253-018-9237-5
Streptomyces rochei
NCBITaxon:1928
LOTUS DOI:10.3389/FMICB.2019.00915

Biosynthetic gene clusters 2

AccessionHostLocus evidenceGenome
mibig:BGC0000031 Streptomyces parvulus
NCBITaxon:146923
CLUSTER_DEMONSTRATED genbank:AJ580915.1
mibig:BGC0001533 Streptomyces rochei
NCBITaxon:1928
CLUSTER_UNSTATED genbank:KT362046.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Open questions 1

shared-structure — This structure is reported by more than one MIBiG entry: BGC0000031, BGC0001533. Confirm they describe the same compound rather than an upstream cross-reference error.

Provenance

Source conceptSourceVersion
BGC0000031MIBIG5
BGC0001533MIBIG5

This page is generated from data/natural_products/polyketides/borrelidin.yaml, which is generated from the committed inventories. Neither is edited by hand.