C-1027 chromophore
CHEBI:3252 EXACT SEEDED antimicrobial unspecified
An enediyne antibiotic that has formula C43H42ClN3O13. It is a natural product found in Streptomyces globisporus and exhibits antimicrobial and antineoplastic properties.
Structure
| Standard InChIKey | DGGZCXUXASNDAC-QQNGCVSVSA-N |
|---|---|
| SMILES | CC1([C@H]([C@H]([C@H]([C@@H](O1)O[C@]23C=CC=C2C#C/C/4=C\C#C[C@H]3OC5=C(C=C(C=C5Cl)[C@H](CC(=O)OC[C@@H]4OC(=O)C6=CC(=CC7=C6NC(=O)C(=C)O7)OC)N)O)O)O)N(C)C)C |
| Stereochemistry | fully defined |
| Cross-references | pubchem:9962646 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces globisporus C-1027 NCBITaxon:1172567 |
SOURCE_ASSERTION | mibig:BGC0001397 | PMID:26853480 |
Occurrences 11
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces sp. CB02366 NCBITaxon:1703935 |
CHEBI | PMID:29345939 |
| Streptomyces sp. CB00657 NCBITaxon:1718958 |
CHEBI | PMID:29345939 |
| Streptomyces sp. CB02329 NCBITaxon:171897 |
CHEBI | PMID:29345939 |
| Streptomyces sp. CB03608 NCBITaxon:1718988 |
CHEBI | PMID:29345939 |
| Streptomyces globisporus NCBITaxon:1908 |
LOTUS | DOI:10.1016/J.JBIOTEC.2016.02.004 |
| Streptomyces globisporus NCBITaxon:1908 |
LOTUS | DOI:10.1021/NP100825Y |
| Streptomyces globisporus NCBITaxon:1908 |
LOTUS | DOI:10.1107/S0907444993002719 |
| Streptomyces globisporus NCBITaxon:1908 |
LOTUS | DOI:10.1128/JB.00797-12 |
| Streptomyces globisporus NCBITaxon:1908 |
LOTUS | DOI:10.1534/G3.119.400037 |
| Streptomyces globisporus NCBITaxon:1908 |
CHEBI | PMID:21250756 |
| Streptomyces globisporus C-1027 NCBITaxon:1172567 |
CHEBI | PMID:3198491 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001397 | Streptomyces globisporus C-1027 NCBITaxon:1172567 |
CLUSTER_UNSTATED | genbank:CP013739.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Elsewhere in the fleet
- AntibioticMech — CHEBI:3252 (same structure, same inchikey)
Open questions 1
name-disagreement — ChEBI calls this structure 'C-1027 chromophore' and MIBiG calls it 'lidamycin'. They share a Standard InChIKey, so if the names denote different compounds then one upstream record has the wrong structure. Check which.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001397 | MIBIG | 5 |
| CHEBI:3252 | CHEBI | 3-star |
This page is generated from data/natural_products/polyketides/c-1027-chromophore.yaml, which is generated from the committed inventories. Neither is edited by hand.