chelocardin
naturalproductmech:mibig-3b0a47e4fd MINTED SEEDED
Structure
| Standard InChIKey | IRCLZBUBOWPFCH-ONJZCGHCSA-N |
|---|---|
| SMILES | [H][C@@]12CC3=C(C(O)=C4C(O)=C(C)C=CC4=C3C)C(=O)[C@]1(O)C(=O)C(C(C)=O)=C(O)[C@@H]2N |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA018131, pubchem:71402 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Amycolatopsis sulphurea NCBITaxon:76022 |
SOURCE_ASSERTION | mibig:BGC0000208 | PMID:24043447 |
Occurrences 1
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Amycolatopsis sulphurea NCBITaxon:76022 |
LOTUS | DOI:10.1099/MIC.0.070995-0 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000208 | Amycolatopsis sulphurea NCBITaxon:76022 |
CLUSTER_UNSTATED | genbank:KC870000.2 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 5
| Assay | Result | Reference |
|---|---|---|
| OTUD3 deubiquitinase inhibition: Primary qHTS | ACTIVE | pubchem.aid:1645858 |
| UCHL1 deubiquitinase inhibition: Primary qHTS | ACTIVE | pubchem.aid:1645859 |
| USP17 deubiquitinase inhibition: Primary qHTS | ACTIVE | pubchem.aid:1645855 |
| USP28 deubiquitinase inhibition: Primary qHTS | ACTIVE | pubchem.aid:1645857 |
| USP7 deubiquitinase inhibition: Primary qHTS | ACTIVE | pubchem.aid:1645854 |
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000208 | MIBIG | 5 |
This page is generated from data/natural_products/polyketides/chelocardin.yaml, which is generated from the committed inventories. Neither is edited by hand.