chromomycin A3

naturalproductmech:mibig-4617b5664b MINTED SEEDED cytotoxic

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	QVHQVBUIOBRRIL-WKSBCEQHSA-N
SMILES	[H][C@]1(CC2=C(C(O)=C3C(O)=C(C)C(O[C@H]4C[C@@H](OC(C)=O)[C@@H](O[C@@H]5C[C@@H](O)[C@@H](OC)[C@@H](C)O5)[C@@H](C)O4)=CC3=C2)C(=O)[C@H]1O[C@H]1C[C@@H](O[C@H]2C[C@@H](O[C@H]3C[C@](C)(O)[C@@H](OC(C)=O)[C@H](C)O3)[C@H](O)[C@@H](C)O2)[C@H](O)[C@@H](C)O1)[C@H](OC)C(=O)[C@@H](O)[C@@H](C)O
Stereochemistry	fully defined
Cross-references	npatlas:NPA016129, pubchem:5351560

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, saccharide, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptomyces griseus subsp. griseus NCBITaxon:67263	BGC_CHARACTERIZED	mibig:BGC0000210	PMID:21342468

Occurrences 0

None cited.

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0000210	Streptomyces griseus subsp. griseus NCBITaxon:67263	CLUSTER_DEMONSTRATED	genbank:AJ578458.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 25

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Explore across X-Mech

AntibioticMech (chromomycin A3) ↗ MediaIngredientMech (naturalproductmech:mibig-4617b5664b) ↗ TaxonMech: Streptomyces griseus subsp. griseus (NCBITaxon:67263) ↗ PathwayMech (mibig:BGC0000210) ↗

Provenance

Source concept	Source	Version
BGC0000210	MIBIG	5

This page is generated from data/natural_products/polyketides/chromomycin-a3.yaml, which is generated from the committed inventories. Neither is edited by hand.

Assay	Result	Target enzyme	Source detail
NCI In Vivo Anticancer Drug Screen. Data for tumor model B16 Melanoma (intraperitoneal) in B6C3F1 mice	ACTIVE	Not recorded	pubchem.aid:200 assay NCI In Vivo Anticancer Drug Screen. Data for tumor model B16 Melanoma (intraperitoneal) in B6C3F1 mice evidence reference pubchem.aid:200 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 200, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI In Vivo Anticancer Drug Screen. Data for tumor model B16 Melanoma (intraperitoneal) in B6D2F1 (BDF1) mice	ACTIVE	Not recorded	pubchem.aid:192 assay NCI In Vivo Anticancer Drug Screen. Data for tumor model B16 Melanoma (intraperitoneal) in B6D2F1 (BDF1) mice evidence reference pubchem.aid:192 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 192, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI In Vivo Anticancer Drug Screen. Data for tumor model Colon Carcinoma 38 (subcutaneous) in B6D2F1 (BDF1) mice	ACTIVE	Not recorded	pubchem.aid:212 assay NCI In Vivo Anticancer Drug Screen. Data for tumor model Colon Carcinoma 38 (subcutaneous) in B6D2F1 (BDF1) mice evidence reference pubchem.aid:212 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 212, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI In Vivo Anticancer Drug Screen. Data for tumor model Human Amelanotic Melanoma (LOX) (intraperitoneal) in NU/NU BALB/C (nude) mice	ACTIVE	Not recorded	pubchem.aid:280 assay NCI In Vivo Anticancer Drug Screen. Data for tumor model Human Amelanotic Melanoma (LOX) (intraperitoneal) in NU/NU BALB/C (nude) mice evidence reference pubchem.aid:280 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 280, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI In Vivo Anticancer Drug Screen. Data for tumor model L1210 Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice	ACTIVE	Not recorded	pubchem.aid:248 assay NCI In Vivo Anticancer Drug Screen. Data for tumor model L1210 Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice evidence reference pubchem.aid:248 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 248, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice	ACTIVE	Not recorded	pubchem.aid:328 assay NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice evidence reference pubchem.aid:328 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 328, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia (intraperitoneal) in CD2F1 (CDF1) mice	ACTIVE	Not recorded	pubchem.aid:330 assay NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia (intraperitoneal) in CD2F1 (CDF1) mice evidence reference pubchem.aid:330 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 330, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI In Vivo Anticancer Drug Screen. Data for tumor model Sarcoma M5076 (intraperitoneal) in B6D2F1 (BDF1) mice	ACTIVE	Not recorded	pubchem.aid:286 assay NCI In Vivo Anticancer Drug Screen. Data for tumor model Sarcoma M5076 (intraperitoneal) in B6D2F1 (BDF1) mice evidence reference pubchem.aid:286 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 286, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the 786-0 Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794775 assay NCI human tumor cell line growth inhibition assay. Data for the 786-0 Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794775 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794775, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the 786-0 Renal cell line	ACTIVE	Not recorded	pubchem.aid:137 assay NCI human tumor cell line growth inhibition assay. Data for the 786-0 Renal cell line evidence reference pubchem.aid:137 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 137, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the A498 Renal cell line	ACTIVE	Not recorded	pubchem.aid:129 assay NCI human tumor cell line growth inhibition assay. Data for the A498 Renal cell line evidence reference pubchem.aid:129 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 129, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line	ACTIVE	Not recorded	pubchem.aid:19 assay NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line evidence reference pubchem.aid:19 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 19, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794740 assay NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794740 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794740, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the ACHN Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794771 assay NCI human tumor cell line growth inhibition assay. Data for the ACHN Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794771 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794771, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line	ACTIVE	Not recorded	pubchem.aid:139 assay NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line evidence reference pubchem.aid:139 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 139, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the BT-549 Breast cell line	ACTIVE	Not recorded	pubchem.aid:89 assay NCI human tumor cell line growth inhibition assay. Data for the BT-549 Breast cell line evidence reference pubchem.aid:89 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 89, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the BT-549 Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794793 assay NCI human tumor cell line growth inhibition assay. Data for the BT-549 Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794793 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794793, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794772 assay NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794772 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794772, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Renal cell line	ACTIVE	Not recorded	pubchem.aid:131 assay NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Renal cell line evidence reference pubchem.aid:131 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 131, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Leukemia cell line	ACTIVE	Not recorded	pubchem.aid:119 assay NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Leukemia cell line evidence reference pubchem.aid:119 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 119, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794778 assay NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794778 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794778, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the COLO 205 Colon cell line	ACTIVE	Not recorded	pubchem.aid:67 assay NCI human tumor cell line growth inhibition assay. Data for the COLO 205 Colon cell line evidence reference pubchem.aid:67 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 67, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the COLO 205 Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794742 assay NCI human tumor cell line growth inhibition assay. Data for the COLO 205 Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794742 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794742, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the DLD-1 Colon cell line	ACTIVE	Not recorded	pubchem.aid:69 assay NCI human tumor cell line growth inhibition assay. Data for the DLD-1 Colon cell line evidence reference pubchem.aid:69 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 69, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the DMS 114 Small Cell Lung cell line	ACTIVE	Not recorded	pubchem.aid:63 assay NCI human tumor cell line growth inhibition assay. Data for the DMS 114 Small Cell Lung cell line evidence reference pubchem.aid:63 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 63, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC notes 107 further PubChem assay results are in data/raw/pubchem_bioassay.tsv but not written here.