cinerubin B

naturalproductmech:mibig-80ef61b944 MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	ZBDDFHXUDIPRSM-DQCCILMQSA-N
SMILES	[H][C@]12C[C@H](O[C@@H]3[C@H](C)O[C@H](C[C@@H]3N(C)C)O[C@H]3C[C@](O)(CC)[C@H](C(=O)OC)C4=CC5=C(C(O)=C34)C(=O)C3=C(O)C=CC(O)=C3C5=O)O[C@@H](C)[C@@]1([H])O[C@]1([H])O[C@@H](C)C(=O)C[C@]1([H])O2
Stereochemistry	fully defined
Cross-references	npatlas:NPA019994

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptomyces sp. SPB074 NCBITaxon:465543	SOURCE_ASSERTION	mibig:BGC0000212	PMID:24191063

Occurrences 13

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Streptomyces NCBITaxon:1883	LOTUS	DOI:10.1002/CBER.19590920820
Streptomyces griseoruber NCBITaxon:1943	LOTUS	DOI:10.1271/BBB.110251
Streptomyces griseoruber NCBITaxon:1943	LOTUS	DOI:10.7164/ANTIBIOTICS.33.49
Streptomyces galilaeus NCBITaxon:33899	LOTUS	DOI:10.7164/ANTIBIOTICS.34.951
Streptomyces eurythermus NCBITaxon:42237	LOTUS	DOI:10.7164/ANTIBIOTICS.45.1599
Streptomyces griseorubiginosus NCBITaxon:67304	LOTUS	DOI:10.1271/BBB.110251
Streptomyces griseorubiginosus NCBITaxon:67304	LOTUS	DOI:10.7164/ANTIBIOTICS.33.49
Streptomyces melanogenes NCBITaxon:67326	LOTUS	DOI:10.1271/BBB.110251
Streptomyces melanogenes NCBITaxon:67326	LOTUS	DOI:10.7164/ANTIBIOTICS.33.49
Streptomyces noboritoensis NCBITaxon:67337	LOTUS	DOI:10.1271/BBB.110251
Streptomyces noboritoensis NCBITaxon:67337	LOTUS	DOI:10.7164/ANTIBIOTICS.33.49
Streptomyces tauricus NCBITaxon:68274	LOTUS	DOI:10.1271/BBB.110251
Streptomyces tauricus NCBITaxon:68274	LOTUS	DOI:10.7164/ANTIBIOTICS.33.49

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0000212	Streptomyces sp. SPB074 NCBITaxon:465543	CLUSTER_UNSTATED	genbank:GG770539.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Explore across X-Mech

AntibioticMech (cinerubin B) ↗ MediaIngredientMech (naturalproductmech:mibig-80ef61b944) ↗ TaxonMech: Streptomyces sp. SPB074 (NCBITaxon:465543) ↗ PathwayMech (mibig:BGC0000212) ↗

Provenance

Source concept	Source	Version
BGC0000212	MIBIG	5

This page is generated from data/natural_products/polyketides/cinerubin-b.yaml, which is generated from the committed inventories. Neither is edited by hand.