concanamycin A
CHEBI:73167 EXACT SEEDED antifungal
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
A concanamycin in which the lactone ring contains 4 double bonds and is substituted by 4 methyl groups, 2 hydroxy groups, 2 methoxy groups and an ethyl group.
Structure
| Standard InChIKey | DJZCTUVALDDONK-HQMSUKCRSA-N |
|---|---|
| SMILES | [H][C@@]1(OC(=O)\C(OC)=C\C(\C)=C\[C@@H](C)[C@@H](O)[C@@H](CC)[C@@H](O)[C@H](C)C\C(C)=C\C=C\[C@@H]1OC)[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](O[C@H]2C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O2)[C@H](C)[C@H](O1)\C=C\C |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA014456, pubchem:6917059 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces neyagawaensis NCBITaxon:42238 |
SOURCE_ASSERTION | mibig:BGC0000040 | PMID:16207901 |
Occurrences 8
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.1002/HLCA.19930760109 |
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.3186/JJPHYTOPATH.62.411 |
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.7164/ANTIBIOTICS.37.1738 |
| Streptomyces purpurascens NCBITaxon:1924 |
LOTUS | DOI:10.7164/ANTIBIOTICS.48.12 |
| Streptomyces violaceus NCBITaxon:1936 |
LOTUS | DOI:10.7164/ANTIBIOTICS.48.12 |
| Streptomyces diastatochromogenes NCBITaxon:42236 |
LOTUS | DOI:10.7164/ANTIBIOTICS.35.1618 |
| Streptomyces diastatochromogenes NCBITaxon:42236 |
LOTUS | DOI:10.7164/ANTIBIOTICS.37.1333 |
| Streptomyces neyagawaensis NCBITaxon:42238 |
LOTUS | DOI:10.1099/MIC.0.28194-0 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000040 | Streptomyces neyagawaensis NCBITaxon:42238 |
CLUSTER_UNSTATED | genbank:DQ149987.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
Elsewhere in the fleet
- AntibioticMech — CHEBI:73167 (same structure, same inchikey)
Explore across X-Mech
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000040 | MIBIG | 5 |
| CHEBI:73167 | CHEBI | 3-star |
This page is generated from data/natural_products/polyketides/concanamycin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.