curacin A
naturalproductmech:mibig-9ff63b44d1 MINTED SEEDED
Structure
| Standard InChIKey | LUEYTMPPCOCKBX-RLAAQAFRSA-N |
|---|---|
| SMILES | CO[C@H](CC\C(C)=C\C=C\CC\C=C/[C@H]1CSC(=N1)[C@@H]1C[C@@H]1C)CC=C |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA03438, pubchem:6438908, CHEBI:3961, chembl:CHEMBL89138 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, from MIBiG.
Producer organisms 2
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Moorea producens 3L NCBITaxon:489825 |
BGC_CORRELATED | mibig:BGC0000976 | PMID:15332855 |
| Moorea producens 19L NCBITaxon:276768 |
SOURCE_ASSERTION | mibig:BGC0000043 | DOI:10.1021/jo00085a006 |
Occurrences 1
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Lyngbya majuscula NCBITaxon:158786 |
LOTUS | DOI:10.1021/JO00085A006 |
Biosynthetic gene clusters 2
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000976 | Moorea producens 3L NCBITaxon:489825 |
CLUSTER_DEMONSTRATED | genbank:HQ696500.1 |
| mibig:BGC0000043 | Moorea producens 19L NCBITaxon:276768 |
CLUSTER_UNSTATED | genbank:GQ412749.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0000043, BGC0000976. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000976 | MIBIG | 5 |
| BGC0000043 | MIBIG | 5 |
This page is generated from data/natural_products/polyketides/curacin-a-2.yaml, which is generated from the committed inventories. Neither is edited by hand.