dehydrocurvularin
naturalproductmech:mibig-124d23f1e5 MINTED SEEDED enzyme inhibitor
Structure
| Standard InChIKey | AVIRMQMUBGNCKS-GQCTYLIASA-N |
|---|---|
| SMILES | CC1CCC\C=C\C(=O)C2=C(O)C=C(O)C=C2CC(=O)O1 |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | npatlas:NPA04907, pubchem:6438143 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Aspergillus terreus NCBITaxon:33178 |
SOURCE_ASSERTION | mibig:BGC0000045 | DOI:10.1007/s10495-023-01811-x |
Occurrences 1
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Aspergillus terreus NCBITaxon:33178 |
LOTUS | DOI:10.1128/AEM.03334-12 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000045 | Aspergillus terreus NCBITaxon:33178 |
CLUSTER_UNSTATED | genbank:JX971534.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 5
| Assay | Result | Reference |
|---|---|---|
| Counterscreen for antagonists of COUP-TFII (NR2F2): Luminescence-based cell-based high throughput assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) | ACTIVE | pubchem.aid:687007 |
| Counterscreen for inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2): Luminescence-based cell-based high throughput assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) | ACTIVE | pubchem.aid:652007 |
| Luminescence-based cell-based high throughput confirmation assay to identify inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2) | ACTIVE | pubchem.aid:652008 |
| Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of COUP-TFII (NR2F2) | ACTIVE | pubchem.aid:686940 |
| Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2) | ACTIVE | pubchem.aid:651957 |
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000045 | MIBIG | 3 |
This page is generated from data/natural_products/polyketides/dehydrocurvularin.yaml, which is generated from the committed inventories. Neither is edited by hand.