dehydrocurvularin

naturalproductmech:mibig-124d23f1e5 MINTED SEEDED enzyme inhibitor

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	AVIRMQMUBGNCKS-GQCTYLIASA-N
SMILES	CC1CCC\C=C\C(=O)C2=C(O)C=C(O)C=C2CC(=O)O1
Stereochemistry	undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-references	npatlas:NPA04907, pubchem:6438143

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Aspergillus terreus NCBITaxon:33178	SOURCE_ASSERTION	mibig:BGC0000045	DOI:10.1007/s10495-023-01811-x

Occurrences 1

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Aspergillus terreus NCBITaxon:33178	LOTUS	DOI:10.1128/AEM.03334-12

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0000045	Aspergillus terreus NCBITaxon:33178	CLUSTER_UNSTATED	genbank:JX971534.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 5

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Assay	Result	Target enzyme	Source detail
Counterscreen for antagonists of COUP-TFII (NR2F2): Luminescence-based cell-based high throughput assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16)	ACTIVE	Not recorded	pubchem.aid:687007 assay Counterscreen for antagonists of COUP-TFII (NR2F2): Luminescence-based cell-based high throughput assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) evidence reference pubchem.aid:687007 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 687007, deposited by The Scripps Research Institute Molecular Screening Center; assay type Screening. Target accession NP_044650 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE activity class ENZYME_INHIBITOR
Counterscreen for inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2): Luminescence-based cell-based high throughput assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16)	ACTIVE	Not recorded	pubchem.aid:652007 assay Counterscreen for inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2): Luminescence-based cell-based high throughput assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) evidence reference pubchem.aid:652007 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 652007, deposited by The Scripps Research Institute Molecular Screening Center; assay type Screening. Target accession NP_044650 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE activity class ENZYME_INHIBITOR
Luminescence-based cell-based high throughput confirmation assay to identify inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2)	ACTIVE	Not recorded	pubchem.aid:652008 assay Luminescence-based cell-based high throughput confirmation assay to identify inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2) evidence reference pubchem.aid:652008 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 652008, deposited by The Scripps Research Institute Molecular Screening Center; assay type Screening. Target accession NP_006531 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE activity class ENZYME_INHIBITOR
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of COUP-TFII (NR2F2)	ACTIVE	Not recorded	pubchem.aid:686940 assay Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of COUP-TFII (NR2F2) evidence reference pubchem.aid:686940 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 686940, deposited by The Scripps Research Institute Molecular Screening Center; assay type Screening. Target accession NP_066285 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE activity class ENZYME_INHIBITOR
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2)	ACTIVE	Not recorded	pubchem.aid:651957 assay Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2) evidence reference pubchem.aid:651957 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 651957, deposited by The Scripps Research Institute Molecular Screening Center; assay type Screening. Target accession NP_006531 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE activity class ENZYME_INHIBITOR

Explore across X-Mech

AntibioticMech (dehydrocurvularin) ↗ MediaIngredientMech (naturalproductmech:mibig-124d23f1e5) ↗ TaxonMech: Aspergillus terreus (NCBITaxon:33178) ↗ PathwayMech (mibig:BGC0000045) ↗

Provenance

Source concept	Source	Version
BGC0000045	MIBIG	3

This page is generated from data/natural_products/polyketides/dehydrocurvularin.yaml, which is generated from the committed inventories. Neither is edited by hand.