dehydrorabelomycin
CHEBI:31461 EXACT SEEDED
Structure
| Standard InChIKey | PQVIKROZFPIERS-UHFFFAOYSA-N |
|---|---|
| SMILES | CC1=CC(=C2C(=C1)C=C(C3=C2C(=O)C4=C(C3=O)C(=CC=C4)O)O)O |
| Stereochemistry | fully defined |
| Cross-references | pubchem:443801 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| uncultured bacterium BAC AB649/1850 NCBITaxon:1037453 |
SOURCE_ASSERTION | mibig:BGC0000223 | PMID:20690632 |
Occurrences 7
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.7164/ANTIBIOTICS.51.1105 |
| Streptomyces griseus NCBITaxon:1911 |
LOTUS | DOI:10.1016/J.PHYTOCHEM.2005.04.010 |
| Streptomyces lividans NCBITaxon:1916 |
LOTUS | DOI:10.3389/FMICB.2018.03042 |
| Streptomyces murayamaensis NCBITaxon:224537 |
LOTUS | DOI:10.1021/JA00051A052 |
| Streptomyces murayamaensis NCBITaxon:224537 |
LOTUS | DOI:10.1021/JA00251A045 |
| Streptomyces murayamaensis NCBITaxon:224537 |
LOTUS | DOI:10.7164/ANTIBIOTICS.42.179 |
| Streptomyces murayamaensis NCBITaxon:224537 |
LOTUS | DOI:10.7164/ANTIBIOTICS.42.189 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000223 | uncultured bacterium BAC AB649/1850 NCBITaxon:1037453 |
CLUSTER_DEMONSTRATED | genbank:HM193369.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 11
| Assay | Result | Reference |
|---|---|---|
| OTUD3 deubiquitinase inhibition: Dose-response Confirmation | ACTIVE | pubchem.aid:1645868 |
| OTUD3 deubiquitinase inhibition: Primary qHTS | ACTIVE | pubchem.aid:1645858 |
| UCHL1 deubiquitinase inhibition: Primary qHTS | ACTIVE | pubchem.aid:1645859 |
| USP10 deubiquitinase inhibition: Dose-response Confirmation | ACTIVE | pubchem.aid:1645863 |
| USP17 deubiquitinase inhibition: Dose-response Confirmation | ACTIVE | pubchem.aid:1645864 |
| USP17 deubiquitinase inhibition: Primary qHTS | ACTIVE | pubchem.aid:1645855 |
| USP28 deubiquitinase inhibition: Dose-response Confirmation | ACTIVE | pubchem.aid:1645866 |
| USP28 deubiquitinase inhibition: Primary qHTS | ACTIVE | pubchem.aid:1645857 |
| USP7 deubiquitinase inhibition: Dose-response Confirmation | ACTIVE | pubchem.aid:1645861 |
| USP7 deubiquitinase inhibition: Primary qHTS | ACTIVE | pubchem.aid:1645854 |
| USP8 deubiquitinase inhibition: Dose-response Confirmation | ACTIVE | pubchem.aid:1645862 |
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000223 | MIBIG | 5 |
| CHEBI:31461 | CHEBI | 3-star |
This page is generated from data/natural_products/polyketides/dehydrorabelomycin.yaml, which is generated from the committed inventories. Neither is edited by hand.