difficidin
naturalproductmech:mibig-40f15fe8fd MINTED SEEDED
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
Structure
| Standard InChIKey | ZUWUQYGHRURWCL-UHFFFAOYSA-N |
|---|---|
| SMILES | CC1CC=CC=CC=CCCCC(OP(O)(O)=O)C(C)=CC=CCC(CCC(C)=CC=C)OC(=O)CC1=C |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | npatlas:NPA019912, pubchem:6438594 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Bacillus velezensis FZB42 NCBITaxon:326423 |
BGC_CHARACTERIZED | mibig:BGC0000176 | PMID:16707694 |
Occurrences 2
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Bacillus NCBITaxon:1386 |
LOTUS | DOI:10.7164/ANTIBIOTICS.40.1677 |
| Bacillus velezensis NCBITaxon:492670 |
LOTUS | DOI:10.1128/JB.00052-06 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000176 | Bacillus velezensis FZB42 NCBITaxon:326423 |
CLUSTER_DEMONSTRATED | genbank:AJ634062.2 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
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Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000176 | MIBIG | 5 |
This page is generated from data/natural_products/polyketides/difficidin.yaml, which is generated from the committed inventories. Neither is edited by hand.