dinactin

naturalproductmech:mibig-cb9f939b3a MINTED SEEDED cytotoxic

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	ZBDGIMZKOJALMU-UHFFFAOYSA-N
SMILES	CCC1CC2CCC(O2)C(C(=O)OC(CC3CCC(O3)C(C(=O)OC(CC4CCC(O4)C(C(=O)OC(CC5CCC(O5)C(C(=O)O1)C)C)C)CC)C)C)C
Stereochemistry	undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-references	pubchem:248000

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 2

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptomyces griseus subsp. griseus NCBITaxon:67263	SOURCE_ASSERTION	mibig:BGC0000243	PMID:10858335
Streptomyces griseus subsp. griseus NCBITaxon:67263	SOURCE_ASSERTION	mibig:BGC0000244	PMID:10858335

Occurrences 0

None cited.

Biosynthetic gene clusters 2

Accession	Host	Locus evidence	Genome
mibig:BGC0000243	Streptomyces griseus subsp. griseus NCBITaxon:67263	CLUSTER_UNSTATED	genbank:AF263011.1
mibig:BGC0000244	Streptomyces griseus subsp. griseus NCBITaxon:67263	CLUSTER_UNSTATED	genbank:AF263012.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 6

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Assay	Result	Target enzyme	Source detail
NCI Yeast Anticancer Drug Screen. Data for the bub3 strain	ACTIVE	Not recorded	pubchem.aid:167 assay NCI Yeast Anticancer Drug Screen. Data for the bub3 strain evidence reference pubchem.aid:167 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 167, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the cln2 rad14 strain	ACTIVE	Not recorded	pubchem.aid:165 assay NCI Yeast Anticancer Drug Screen. Data for the cln2 rad14 strain evidence reference pubchem.aid:165 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 165, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the mec2-1 strain	ACTIVE	Not recorded	pubchem.aid:157 assay NCI Yeast Anticancer Drug Screen. Data for the mec2-1 strain evidence reference pubchem.aid:157 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 157, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the mlh1 rad18 strain	ACTIVE	Not recorded	pubchem.aid:175 assay NCI Yeast Anticancer Drug Screen. Data for the mlh1 rad18 strain evidence reference pubchem.aid:175 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 175, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the rad50 strain	ACTIVE	Not recorded	pubchem.aid:155 assay NCI Yeast Anticancer Drug Screen. Data for the rad50 strain evidence reference pubchem.aid:155 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 155, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the sgs1 mgt1 strain	ACTIVE	Not recorded	pubchem.aid:161 assay NCI Yeast Anticancer Drug Screen. Data for the sgs1 mgt1 strain evidence reference pubchem.aid:161 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 161, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC

Explore across X-Mech

AntibioticMech (dinactin) ↗ MediaIngredientMech (naturalproductmech:mibig-cb9f939b3a) ↗ TaxonMech: Streptomyces griseus subsp. griseus (NCBITaxon:67263) ↗ TaxonMech: Streptomyces griseus subsp. griseus (NCBITaxon:67263) ↗ PathwayMech (mibig:BGC0000243) ↗ PathwayMech (mibig:BGC0000244) ↗

Open questions 1

shared-structure — This structure is reported by more than one MIBiG entry: BGC0000243, BGC0000244. Confirm they describe the same compound rather than an upstream cross-reference error.

Provenance

Source concept	Source	Version
BGC0000243	MIBIG	4
BGC0000244	MIBIG	4

This page is generated from data/natural_products/polyketides/dinactin.yaml, which is generated from the committed inventories. Neither is edited by hand.