dinactin
naturalproductmech:mibig-cb9f939b3a MINTED SEEDED cytotoxic
Structure
| Standard InChIKey | ZBDGIMZKOJALMU-UHFFFAOYSA-N |
|---|---|
| SMILES | CCC1CC2CCC(O2)C(C(=O)OC(CC3CCC(O3)C(C(=O)OC(CC4CCC(O4)C(C(=O)OC(CC5CCC(O5)C(C(=O)O1)C)C)C)CC)C)C)C |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | pubchem:248000 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 2
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces griseus subsp. griseus NCBITaxon:67263 |
SOURCE_ASSERTION | mibig:BGC0000243 | PMID:10858335 |
| Streptomyces griseus subsp. griseus NCBITaxon:67263 |
SOURCE_ASSERTION | mibig:BGC0000244 | PMID:10858335 |
Occurrences 0
None cited.
Biosynthetic gene clusters 2
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000243 | Streptomyces griseus subsp. griseus NCBITaxon:67263 |
CLUSTER_UNSTATED | genbank:AF263011.1 |
| mibig:BGC0000244 | Streptomyces griseus subsp. griseus NCBITaxon:67263 |
CLUSTER_UNSTATED | genbank:AF263012.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 6
| Assay | Result | Reference |
|---|---|---|
| NCI Yeast Anticancer Drug Screen. Data for the bub3 strain | ACTIVE | pubchem.aid:167 |
| NCI Yeast Anticancer Drug Screen. Data for the cln2 rad14 strain | ACTIVE | pubchem.aid:165 |
| NCI Yeast Anticancer Drug Screen. Data for the mec2-1 strain | ACTIVE | pubchem.aid:157 |
| NCI Yeast Anticancer Drug Screen. Data for the mlh1 rad18 strain | ACTIVE | pubchem.aid:175 |
| NCI Yeast Anticancer Drug Screen. Data for the rad50 strain | ACTIVE | pubchem.aid:155 |
| NCI Yeast Anticancer Drug Screen. Data for the sgs1 mgt1 strain | ACTIVE | pubchem.aid:161 |
Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0000243, BGC0000244. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000243 | MIBIG | 4 |
| BGC0000244 | MIBIG | 4 |
This page is generated from data/natural_products/polyketides/dinactin.yaml, which is generated from the committed inventories. Neither is edited by hand.