ebelactone B

naturalproductmech:mibig-8ffa6e142d MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	UNBMQQNYLCPCHS-VYNDPHDASA-N
SMILES	CC[C@H]1[C@@H](OC1=O)[C@@H](C)C/C(=C/[C@@H](C)C(=O)[C@@H](C)[C@@H]([C@H](C)CC)O)/C
Stereochemistry	fully defined
Cross-references	pubchem:6436821

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Kitasatospora aburaviensis NCBITaxon:67265	SOURCE_ASSERTION	mibig:BGC0000051	PMID:23801186

Occurrences 1

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Streptomyces NCBITaxon:1883	LOTUS	DOI:10.7164/ANTIBIOTICS.35.1495

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0000051	Kitasatospora aburaviensis NCBITaxon:67265	CLUSTER_UNSTATED	genbank:KC894072.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 1

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Assay	Result	Target enzyme	Source detail
qHTS for Inhibitors of Polymerase Kappa	OTHER 33.5875 uM; NOT_DETERMINED	Not recorded	pubchem.aid:588579 assay qHTS for Inhibitors of Polymerase Kappa evidence reference pubchem.aid:588579 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 588579, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_057302 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 33.5875 units uM

Explore across X-Mech

AntibioticMech (ebelactone B) ↗ MediaIngredientMech (naturalproductmech:mibig-8ffa6e142d) ↗ TaxonMech: Kitasatospora aburaviensis (NCBITaxon:67265) ↗ PathwayMech (mibig:BGC0000051) ↗

Provenance

Source concept	Source	Version
BGC0000051	MIBIG	5

This page is generated from data/natural_products/polyketides/ebelactone-b.yaml, which is generated from the committed inventories. Neither is edited by hand.