erythromycin B
CHEBI:28196 EXACT SEEDED antimicrobial unspecified
An erythromycin that consists of erythronolide B having 2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.
Structure
| Standard InChIKey | IDRYSCOQVVUBIJ-PPGFLMPOSA-N |
|---|---|
| SMILES | CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@H]1C |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA015585, pubchem:10702, chembl:CHEMBL3220708 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, saccharide, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Saccharopolyspora erythraea NRRL 2338 NCBITaxon:405948 |
BGC_CHARACTERIZED | mibig:BGC0000055 | PMID:11336289 |
Occurrences 2
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Saccharopolyspora erythraea NCBITaxon:1836 |
LOTUS | DOI:10.1016/0040-4039(91)80057-D |
| Saccharopolyspora erythraea NCBITaxon:1836 |
LOTUS | DOI:10.1021/JA01631A070 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000055 | Saccharopolyspora erythraea NRRL 2338 NCBITaxon:405948 |
CLUSTER_DEMONSTRATED | genbank:AM420293.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Elsewhere in the fleet
- AntibioticMech — CHEBI:28196 (same structure, same inchikey)
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000055 | MIBIG | 5 |
| CHEBI:28196 | CHEBI | 3-star |
This page is generated from data/natural_products/polyketides/erythromycin-b.yaml, which is generated from the committed inventories. Neither is edited by hand.